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Darzens reaction in the synthesis of 3-(α-chloroalkyl)quinoxalin-2(1H)-ones

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Abstract

A two-stage method was developed for the synthesis of 3-(α-chloroalkyl- and α-chlorophenylalkyl)-quinoxalin-2(1H)-ones proceeding from methyl chloroalkyl- and chlorophenylalkylpyruvates obtained by Darzens reaction from methyl dichloroacetate and appropriate aldehydes in the presence of t-BuOK.

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Authors and Affiliations

  1. Arbuzov Institute of Organic and Physical Chemistry, Kazan’ Scientific Center, Russian Academy of Sciences, Kazan’, 420088, Russia

    D. F. Saifina, V. R. Ganieva & V. A. Mamedov

Authors
  1. D. F. Saifina
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  2. V. R. Ganieva
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  3. V. A. Mamedov
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Correspondence to V. A. Mamedov.

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Original Russian Text © D.F. Saifina, V.R. Ganieva, V.A. Mamedov, 2009, published in Zhurnal Organicheskoi Khimii, 2009, Vol. 45, No. 8, pp. 1252–1255.

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Saifina, D.F., Ganieva, V.R. & Mamedov, V.A. Darzens reaction in the synthesis of 3-(α-chloroalkyl)quinoxalin-2(1H)-ones. Russ J Org Chem 45, 1244–1247 (2009). https://doi.org/10.1134/S1070428009080223

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  • DOI: https://doi.org/10.1134/S1070428009080223

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