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Synthesis of 3-amino-4,5-dichloroisothiazole

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Abstract

4,5-Dichloro-1,2-thiazol-3-amine was synthesized starting from accessible 4,5-dichloro-1,2-thiazole-3-carbonyl azide and -3-carboxamide via Curtius and Hofmann rearrangements, respectively. The procedure involving Curtius rearrangement was found to be more advantageous from the preparative viewpoint.

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Authors and Affiliations

  1. Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, ul. Surganova 13, Minsk, 220072, Belarus

    V. I. Potkin & Yu. S. Zubenko

Authors
  1. V. I. Potkin
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  2. Yu. S. Zubenko
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Correspondence to V. I. Potkin.

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Original Russian Text © V.I. Potkin, Yu.S. Zubenko, 2009, published in Zhurnal Organicheskoi Khimii, 2009, Vol. 45, No. 4, pp. 568–572.

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Potkin, V.I., Zubenko, Y.S. Synthesis of 3-amino-4,5-dichloroisothiazole. Russ J Org Chem 45, 555–558 (2009). https://doi.org/10.1134/S1070428009040149

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  • DOI: https://doi.org/10.1134/S1070428009040149

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