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Synthesis of analogs of ecdysteroids containing an isoxaline ring in the side chain

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Abstract

Starting with poststerone a synthesis was performed of ecdysteroid analogs containing an isoxaline ring in the side chain. The key stages of the route to the target products were Normant reaction and the subsequent 1,3-dipolar cycloaddition of nitrile oxides to 20-hydroxy-20-vinylsteroids.

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Authors and Affiliations

  1. Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, 220141, Belarus

    R. P. Litvinovskaya, S. V. Drach, G. A. Zhilitskaya & V. A. Khripach

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  1. R. P. Litvinovskaya
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  2. S. V. Drach
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  3. G. A. Zhilitskaya
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  4. V. A. Khripach
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Corresponding author

Correspondence to R. P. Litvinovskaya.

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Original Russian Text © R.P. Litvinovskaya, S.V. Drach, G.A. Zhilitskaya, V.A. Khripach, 2008, published in Zhurnal Organicheskoi Khimii, 2008, Vol. 44, No. 11, pp. 1615–1622.

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Litvinovskaya, R.P., Drach, S.V., Zhilitskaya, G.A. et al. Synthesis of analogs of ecdysteroids containing an isoxaline ring in the side chain. Russ J Org Chem 44, 1590–1597 (2008). https://doi.org/10.1134/S1070428008110043

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  • DOI: https://doi.org/10.1134/S1070428008110043

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