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Synthesis of new purine, pteridine, and other pyrimidine derivatives

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Abstract

The reaction of malononitrile dimer with phenyl isothiocyanate gave (6-amino-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-ylidene)malononitrile which was then used as starting material in the synthesis of pharmacologically important fused pyrimidine derivatives, such as 4-dicyanomethylidene-1,5-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrrolo[2,3-d]pyrimidine, 6-cyano-4-dicyanomethylidene-7-methylsulfanyl-5-oxo-1-phenyl-2-thioxo-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine, 6-dicyanomethylidene-3-phenyl-2-thioxo-1,2,3,6-tetrahydro-9H-purine, and 6-substituted 4-dicyanomethylidene-7-oxo-1-phenyl-2-thioxo-1,2,3,4,7,8-hexahydropteridines.

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Authors and Affiliations

  1. Faculty of Science, Chemistry Department, University of Mansoura, Mansoura, 35516, Egypt

    E. Abdel-Latif, H. M. Mustafa, H. A. Etman & A. A. Fadda

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  1. E. Abdel-Latif
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  2. H. M. Mustafa
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  3. H. A. Etman
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  4. A. A. Fadda
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Additional information

Published in Russian in Zhurnal Organicheskoi Khimii, 2007, Vol. 43, No. 3, pp. 443–449.

The text was submitted by the authors in English.

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Abdel-Latif, E., Mustafa, H.M., Etman, H.A. et al. Synthesis of new purine, pteridine, and other pyrimidine derivatives. Russ J Org Chem 43, 443–448 (2007). https://doi.org/10.1134/S1070428007030219

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  • DOI: https://doi.org/10.1134/S1070428007030219

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