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Synthesis of substituted 2,4-dimethylthieno[3,2-c]quinolines

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Abstract

A procedure was developed for the synthesis of substituted 2,4-dimethylthieno[3,2-c]quinolines via intramolecular cyclization and subsequent aromatization of 3-(2-chloroprop-2-en-1-yl)-and 3-(2-oxopropyl)-2-methylquinoline-4-thiols. The latter were obtained by alkaline hydrolysis of the corresponding thiuronium salts which were prepared in turn by reactions of 4-chloro-3-(2-chloroprop-2-en-1-yl)-and 4-chloro-3-(2-oxopropyl)-2-methylquinolines with thiourea.

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Authors and Affiliations

  1. Erevan State University, ul. A. Manukyana 1, Erevan, 375025, Armenia

    A. A. Avetisyan, I. L. Aleksanyan & K. S. Sargsyan

Authors
  1. A. A. Avetisyan
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  2. I. L. Aleksanyan
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  3. K. S. Sargsyan
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Additional information

Original Russian Text © A.A. Avetisyan, I.L. Aleksanyan, K.S. Sargsyan, 2007, published in Zhurnal Organicheskoi Khimii, 2007, Vol. 43, No. 3, pp. 423–426.

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Avetisyan, A.A., Aleksanyan, I.L. & Sargsyan, K.S. Synthesis of substituted 2,4-dimethylthieno[3,2-c]quinolines. Russ J Org Chem 43, 422–425 (2007). https://doi.org/10.1134/S1070428007030165

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  • DOI: https://doi.org/10.1134/S1070428007030165

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