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A convenient synthesis of 3,4-diaryl(hetaryl)-substituted maleimides and maleic anhydrides

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Abstract

A convenient procedure has been developed for the synthesis of 3,4-diaryl(or hetaryl)maleimides by cross coupling of N-substituted 3,4-dibromomaleimides with aryl(hetaryl)boronic acids in the presence of Pd(Ph3P)4 and CsF. The reaction ensures high yields of the products and requires relatively small amount of the catalyst; it can be performed on an enlarged scale. The resulting maleimides are readily converted into the corresponding maleic anhydrides.

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Authors and Affiliations

  1. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii pr. 47, Moscow, 117913, Russia

    S. V. Shorunov, M. M. Krayushkin & F. M. Stoyanovich

  2. Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Hakozaki 6-10-1, Higashi-ku, 812-8581, Fukuoka, Japan

    M. Irie

Authors
  1. S. V. Shorunov
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  2. M. M. Krayushkin
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  3. F. M. Stoyanovich
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  4. M. Irie
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Additional information

Original Russian Text © S.V. Shorunov, M.M. Krayushkin, F.M. Stoyanovich, M. Irie, 2006, published in Zhurnal Organicheskoi Khimii, 2006, Vol. 42, No. 10, pp. 1504–1511.

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Shorunov, S.V., Krayushkin, M.M., Stoyanovich, F.M. et al. A convenient synthesis of 3,4-diaryl(hetaryl)-substituted maleimides and maleic anhydrides. Russ J Org Chem 42, 1490–1497 (2006). https://doi.org/10.1134/S1070428006100162

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  • DOI: https://doi.org/10.1134/S1070428006100162

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