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One-step solvent-free synthesis of fluoroalkyl-substituted 4-hydroxy-2-oxo(thioxo)hexahydropyrimidines in the presence of 1-butyl-3-methylimidazolium tetrafluoroborate

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Abstract

A convenient procedure has been developed for the synthesis of fluoroalkyl-substituted 6-aryl-4-hydroxy-2-oxo-(thioxo)hexahydropyrimidine derivatives by three-component condensation of fluorinated β-dicarbonyl compounds with aromatic aldehydes and urea or thiourea in the absence of a solvent using 6 mol % of 1-butyl-3-methylimidazolium tetrafluoroborate as catalyst.

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Authors and Affiliations

  1. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii pr. 47, Moscow, 119991, Russia

    E. S. Putilova, N. A. Troitskii & S. G. Zlotin

  2. Institute of Organic Synthesis, Ural Division, Russian Academy of Sciences, ul. S. Kovalevskoi 20, Yekaterinburg, 620219, Russia

    O. G. Khudina, Ya. V. Burgart, V. I. Saloutin & O. N. Chupakhin

Authors
  1. E. S. Putilova
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  2. N. A. Troitskii
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  3. S. G. Zlotin
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  4. O. G. Khudina
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  5. Ya. V. Burgart
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  6. V. I. Saloutin
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  7. O. N. Chupakhin
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Additional information

Original Russian Text © E.S. Putilova, N.A. Troitskii, S.G. Zlotin, O.G. Khudina, Ya.V. Burgart, V.I. Saloutin, O.N. Chupakhin, 2006, published in Zhurnal Organicheskoi Khimii, 2006, Vol. 42, No. 9, pp. 1407–1410.

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Putilova, E.S., Troitskii, N.A., Zlotin, S.G. et al. One-step solvent-free synthesis of fluoroalkyl-substituted 4-hydroxy-2-oxo(thioxo)hexahydropyrimidines in the presence of 1-butyl-3-methylimidazolium tetrafluoroborate. Russ J Org Chem 42, 1392–1395 (2006). https://doi.org/10.1134/S1070428006090259

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  • DOI: https://doi.org/10.1134/S1070428006090259

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