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Gd2O3–Carbon Nanoflakes (CNFs) as Contrast Agents for Photon-Counting Computed Tomography (PCCT)

  • Inorganic Synthesis and Industrial Inorganic Chemistry
  • Published:
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Abstract

2–3 nm Gd2O3 nanoparticles deposited on carbon nanoflakes were prepared. These are new contrast agents for photon-counting computed tomography based on detectors allowing counting of separate photons. Contrast agents of the Gd2O3@C core–shell structure were prepared by graphitization of the surface of these particles. The Gd2O3 and Gd2O3@C nanoparticles obtained, aqueous solution of Gd(NO3)3·6H2O, and a dispersion of 300–500 nm Gd2O3 particles in gelatin were studied by photon-counting computed tomography. At equal gadolinium concentrations, the highest X-ray absorption was noted for Gd(NO3)3·6H2O and Gd2O3, which is associated with higher density of these samples. Carbon in the contrast agents does not affect the absorption. An algorithm was developed for semiquantitative determination of gadolinium by photon-counting computed tomography.

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ACKNOWLEDGMENTS

The authors are sincerely grateful to S.V. Maksimov and Cand. Sci. (Chem.) A.V. Shumyantsev for recording the TEM images and thermograms of the samples, respectively.

Funding

The study was financially supported by the Russian Science Foundation (project 22-15-00072) using the equipment purchased at the expense of the Program for the Development of the Moscow University.

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Authors and Affiliations

  1. Faculty of Basic Medicine, Moscow State University, 119991, Moscow, Russia

    D. A. Shashurin & O. S. Medvedev

  2. Faculty of Chemistry, Moscow State University, 119991, Moscow, Russia

    E. V. Suslova

  3. International Intergovernmental Organisation “Joint Institute for Nuclear Research,” Dubna, 141980, Moscow oblast, Russia

    V. A. Rozhkov, R. V. Sotenskii & G. A. Shelkov

Authors
  1. D. A. Shashurin
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  2. E. V. Suslova
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  3. V. A. Rozhkov
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  4. R. V. Sotenskii
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  5. O. S. Medvedev
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  6. G. A. Shelkov
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Contributions

D.A. Shashurin: development of the scheme of experimental studies, execution of tomographic experiments, data processing; E.V. Suslova: concept and idea of the study, synthesis and analysis of the physicochemical characteristics of the samples; V.A. Rozhkov and R.V. Sotenskii: tomographic experiments, data processing; O.S. Medvedev, G.A. Shelkov: administrative and organizational support of the study.

Corresponding author

Correspondence to E. V. Suslova.

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The authors declare that they have no conflicts of interest.

Additional information

Translated from Zhurnal Prikladnoi Khimii, No. 4, pp. 337–344, August, 2023 https://doi.org/10.31857/S0044461823040023

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Shashurin, D.A., Suslova, E.V., Rozhkov, V.A. et al. Gd2O3–Carbon Nanoflakes (CNFs) as Contrast Agents for Photon-Counting Computed Tomography (PCCT). Russ J Appl Chem 96, 410–416 (2023). https://doi.org/10.1134/S107042722304002X

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