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Optimization of Arabinogalactan Sulfation in Process Scaling

  • Organic Synthesis and Industrial Organic Chemistry
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Abstract

To ensure the safety of the arabinogalactan sulfation process, the thermal effect of the reaction (148.26 kJ) was determined by the thermal flux balance method. The dependence of the dynamic viscosity of the reaction medium on the way of introducing the sulfating agent and on its particle size was studied by phase rheology. The stirring process was calculated to substantiate the optimum stirrer design and determine the quality parameters of stirring of the reaction medium. The data obtained allow optimization of the process for producing Agsular® substance in scaling of the production technology.

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ACKNOWLEDGMENTS

The main experimental data were obtained using the material and technical base of the Baikal Analytical Center for Shared Use, Siberian Branch, Russian Academy of Sciences and of the Research Laboratory of Catalysis and Organic Synthesis, Irkutsk National Research Technical University.

The author is grateful to A.S. Soldatenko (Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences), V.O. Strakhov (Irkutsk National Research Technical University) and M.O. Mel’nikov (SokTreid Ko, Russia) for the assistance in performing this study.

Funding

The study was performed in accordance with the research plan (government assignment), program V.48: Basic Physicochemical Studies of Mechanisms of Physiological Processes and Development on Their Basis of Pharmacological Substances and Drug Forms for Treatment and Prevention of Socially Significant Diseases (2013–2020). Project V.48.1.2: Search for New Biologically Active Compounds Based on the Biomass of Coniferous Plants of Siberia and Far East, Screening of the Biological Activity of Promising Compounds. Development of Technologies for Producing Natural Substances and Determination of Their Practical Significance.

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Authors and Affiliations

  1. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 664033, Irkutsk, Russia

    Ya. A. Kostyro

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  1. Ya. A. Kostyro
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Correspondence to Ya. A. Kostyro.

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Additional information

Translated from Zhurnal Prikladnoi Khimii, No. 1, pp. 95–103, August, 2023 https://doi.org/10.31857/S0044461823010115

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Kostyro, Y.A. Optimization of Arabinogalactan Sulfation in Process Scaling. Russ J Appl Chem 96, 83–90 (2023). https://doi.org/10.1134/S1070427223010111

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