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Antimicrobial Popymers: Homopolymers and Copolymers of Cefotiam-Binding Acrylamide

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Abstract

The object of this article was to synthesize a special type of functional polymer material with antimicrobial activity. In this paper, polymer antibacterial materials were synthesized in two steps: (1) acrylamide–cefotiam was synthesized via acrylate chloride reaction with cefotiam at 0–5°C for 8 h；(2) The poly(acrylamide–cefotiam) and poly(acrylamide-co-acrylamide–cefotiam) were synthesized via free radical polymerization method in 60°C using water as the solvent and ammonium persulfate as the initiator. The chemical structure and composition of the acrylamide–cefotiam and obtained polymers were investigated by Fourier transform infrared (FTIR) spectrum and Nuclear magnetic resonance (NMR) spectroscopy. The number-average molecular weight (Mn) of poly(acrylamide–cefotiam) and poly(acrylamide-co-acrylamide–cefotiam) were determined by gel permeation chromatography (GPC). In order to investigate the effect of the obtained polymers bonding of cefotiam on their antimicrobial properties, the contrast and colony counting were used to investigate the antibacterial properties of polymers against ATCC 8739 E. coli. The polymer bonded to cefotiam has 100% antibacterial properties against ATCC 8739 E. coli. Experimental results provide a new method for preparing antimicrobial polymer materials.

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  1. Hefei no. 1 High School, 230601, Anhui, China

    Baixin Li

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  1. Baixin Li
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Correspondence to Baixin Li.

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Li, B. Antimicrobial Popymers: Homopolymers and Copolymers of Cefotiam-Binding Acrylamide. Russ J Appl Chem 95, 1489–1496 (2022). https://doi.org/10.1134/S1070427222090269

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  • DOI: https://doi.org/10.1134/S1070427222090269

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