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Synthesis and Properties of Polymeric Rifabutin Forms with Different Types of Polymer–Antibiotic Bonding

  • Macromolecular Compounds and Polymeric Materials
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Abstract

Water-soluble polymeric forms of Rifabutin antitubercular drug, based on copolymers of acrylamide with 2-acrylamido-2-methylpropanesulfonic acid and of N-vinylpyrrolidone with 2-aminoethyl methacrylate, with ionic and covalent polymer–Rifabutin bonding were prepared. Polymeric carriers with the molecular mass of 7.5–98 kDa were prepared by radical copolymerization in alcohols at 60°С; the hydrodynamic radii Rh-D of the polymer–Rifabutin complex and initial polymeric carrier were 2.6 and 2.35 nm, respectively. The Rifabutin content of the polymer systems was 14.1–43.4 mol %. The kinetics of the Rifabutin release from the polymeric forms in a model medium was estimated. Both types of the polymeric forms showed high activity toward M. smegmatis ATCC-607.

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ACKNOWLEDGMENTS

The authors are grateful to the staff of the Chair of Microbiology and Virology, Pavlov First St. Petersburg State Medical University for the assistance in microbiological trials of the polymeric forms obtained and to Dr. Sci. (Chem.) N.A. Lavrov for critical analysis of the manuscript.

Funding

The study was performed within the framework of the government assignment of the Ministry of Science and Higher Education of the Russian Federation (theme no. 122012100171-8: Nanostructuring and Modification of Biologically Active Compounds by Synthetic and Natural Polymers).

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Authors and Affiliations

  1. St. Petersburg State Institute of Technology (Technical University), 190013, St. Petersburg, Russia

    A. A. Vagin

  2. Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004, St. Petersburg, Russia

    A. A. Vagin, M. S. Borisenko, M. V. Solovskii & E. B. Tarabukina

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  1. A. A. Vagin
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  2. M. S. Borisenko
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  3. M. V. Solovskii
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  4. E. B. Tarabukina
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Correspondence to M. S. Borisenko.

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Vagin, A.A., Borisenko, M.S., Solovskii, M.V. et al. Synthesis and Properties of Polymeric Rifabutin Forms with Different Types of Polymer–Antibiotic Bonding. Russ J Appl Chem 95, 1311–1321 (2022). https://doi.org/10.1134/S1070427222090051

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  • DOI: https://doi.org/10.1134/S1070427222090051

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