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Synthesis of Selenium Nanoparticles Stabilized with Sodium Carboxymethylcellulose for Preparation of a Long-Acting Form of Prospidine

  • Macromolecular Compounds and Polymeric Materials
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Abstract

Stable selenium nanoparticles were synthesized in a sodium carboxymethylcellulose (Na-CMC) solution with a degree of substitution of 0.85 and an average molar weight of 250 000. The shape and size of selenium nanoparticles were determined by dynamic light scattering and UV spectroscopy. It was found that the nanoparticles coated with Na-CMC are stable upon storage for 28 days. A significant prolongation of the release of the prospidine antitumor agent from stabilized nanoparticles has been shown. Broad spectrum drugs, in particular, anticancer drugs and drugs that compensate for selenium deficiency in the body can be produced based on the selenium nanoparticles coated with Na-CMC.

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Funding

This work was financially supported by the project of the Fund for Support of Fundamental Research of the Academy of Sciences of the Republic of Uzbekistan, vol. 1–18 “Revealing the patterns of the formation of selenium nanoparticles in the polymer structure for the creation of original anticancer drugs” and the international project Uzbekistan–Belarus with financial support from the Ministry of Innovative Development of the Republic of Uzbekistan and Ministry of Education of the Republic of Belarus “Creation of polymer forms of drugs for the treatment of oncological diseases based on selenium nanoparticles stabilized on biodegradable polymer substrates of natural origin.”

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Authors and Affiliations

  1. Institute of Polymer Chemistry and Physics, Academy of Sciences of the Republic Uzbekistan, 700128, Tashkent, Uzbekistan

    Kh. E. Yunusov, A. A. Sarymsakov, F. M. Turakulov & S. Sh. Rashidova

  2. Research Institute of Physicochemical Problems, Belarusian State University, 220030, Minsk, Belarus

    T. L. Yurkshtovich, A. V. Kokhan, N. K. Yurkshtovich, V. A. Alinovskaya, N. V. Golub & S. O. Solomevich

  3. Educational Scientific Production Republican Unitary Enterprise “Unitechprom BSU”, 220045, Minsk, Belarus

    P. M. Bychkovskii

Authors
  1. Kh. E. Yunusov
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  2. A. A. Sarymsakov
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  3. F. M. Turakulov
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  4. S. Sh. Rashidova
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  5. T. L. Yurkshtovich
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  6. A. V. Kokhan
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  7. N. K. Yurkshtovich
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  8. V. A. Alinovskaya
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  9. P. M. Bychkovskii
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  11. S. O. Solomevich
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Correspondence to S. O. Solomevich.

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Translated from Zhurnal Prikladnoi Khimii, No. 9, pp. 1186–1194, January, 2021 https://doi.org/10.31857/S0044461821090085

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Yunusov, K.E., Sarymsakov, A.A., Turakulov, F.M. et al. Synthesis of Selenium Nanoparticles Stabilized with Sodium Carboxymethylcellulose for Preparation of a Long-Acting Form of Prospidine. Russ J Appl Chem 94, 1259–1266 (2021). https://doi.org/10.1134/S1070427221090081

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