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Microparticles based on chitosan–hyaluronic acid interpolyelectrolyte complex, which provide stability of aqueous dispersions

  • Physicochemical Studies of Systems and Processes
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Abstract

Turbidimetric titration and laser scattering methods were used to assess the phase behavior of mixtures of chitosan and hyaluronic acid in aqueous solutions in relation to interaction conditions. Conditions were found in which stable water dispersions with particle size of up to 573 nm can be obtained. It was found that the molar ratios and the overall concentration mode of the starting-polyelectrolyte solutions affect the particle size.

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References

  1. Kumari, S., Nagpal, M., Aggarwal, G., et al., World J. Pharm. Sci., 2016, vol. 5, no. 03, pp. 543–566.

    CAS  Google Scholar 

  2. Harnish, K., Priyanka, R., Tushar, J., et al., Am. J. Pharm. Tech. Res., 2011, vol. 1, no. 4, pp. 108–126.

    Google Scholar 

  3. Kirzhanova, E.A., Pechenkin, M.A., Demina, N.B., and Balabushevich, N.G., Vestn. Mosk. Univ., 2016, vol. 57, no. 2, pp. 103–111.

    Google Scholar 

  4. Yan, X.L., Khor, E., and Lim, L.Y., J. Biomed. Mater. Res., 2001, vol. 58, no. 4, pp. 58–358.

    Article  Google Scholar 

  5. Gazori, T., Khoshayand, M.R., and Azizi, E., Carbohydr. Polym., 2009, vol. 77, no. 3, pp. 599–606.

    Article  CAS  Google Scholar 

  6. Guo, R., Chen, L., Cai, S., et al., J. Mater. Sci. Mater. Med., 2013, vol. 24, no. 9, pp. 2093–2100.

    Article  CAS  Google Scholar 

  7. Badykova, L.A., Mudarisova, R.H., Gurina, M.S., and Borisov, I.M., Russ. J. Appl. Chem., 2016, vol. 89, no. 7, pp. 935–941.

    Article  Google Scholar 

  8. Mitra, S., Gaur, U., Ghosh, P.C., et al., J. Contr. Re l., 2001, vol. 74, pp. 317–323.

    Article  CAS  Google Scholar 

  9. Balabushevich, N.G., Vikhoreva, G.A., Mikhal’chik, E.V., and Larionova, N.I., Vestn. Mosk. Univ., 2010, vol. 51, no. 3, p. 178.

    CAS  Google Scholar 

  10. Kim, S.J., Shin, S.R., Lee, S.M., et al., J. Macromol. Sci., 2003, vol. A40, pp. 807–815.

    Article  CAS  Google Scholar 

  11. Denuziere, A., Ferrier, D., Damour, O., and Domard, A., Biomaterials, 1998, no. 19, pp. 1275–1285.

    Article  CAS  Google Scholar 

  12. Vasiliu, S., Popa, M., and Rinaudo, M., Eur. Polym. J., 2005, no. 41, pp. 923–932.

    Article  CAS  Google Scholar 

  13. Fang, J.Y., Chen, J.P., Leu, Y.L., et al., Eur. J. Pharm. Biopharm., 2008, no. 68, pp. 626–636.

    Article  CAS  Google Scholar 

  14. Oyarzun-Ampuero, F.A., Brea, J., Loza, M.I., et al., Int. J. Pharm., 2009, no. 381, pp. 122–129.

    Article  CAS  Google Scholar 

  15. Deng, X., Cao, M., Zhang, J., et al., Biomaterials, 2014, vol. 35, pp. 4333–4344.

    Article  CAS  Google Scholar 

  16. Vandenberg, G.W., Drolet, C., Scott, S.L., et al., J. Contr. Rel., 2001, vol. 77, no. 3, p. 297.

    Article  CAS  Google Scholar 

  17. Sarmento, B., Ribeiro, A.J., Veiga, F., et al., J Nanosci. Nanotechnol., 2007, vol. 7, no. 8, p. 2833.

    Article  CAS  Google Scholar 

  18. Woitiski, C.B., Neufeld, R.J., Ribeiro, A.J., and Veiga, F., Acta Biomater., 2009, vol. 5, no. 7, p. 2475.

    Article  CAS  Google Scholar 

  19. Ribeiro, A.J., Silva, C., Ferreira, D., and Veiga, F., Eur. J. Pharm. Sci., 2005, vol. 25, no. 1, p. 31.

    Article  CAS  Google Scholar 

  20. Chan, L.W., Lee, H.Y., and Heng, P.W.S., Int. J. Pharm., 2002, vol. 242, nos. 1–2, p. 259.

    Article  CAS  Google Scholar 

  21. Chan, L.W. and Heng, P.W.S., Biomaterials, 2002, vol. 23, no. 5, p. 1319.

    Article  CAS  Google Scholar 

  22. Zorzin, L., Cocchietto, M., Voinovich, D., et al., J. Drug Del. Sci. Tech., 2006, vol. 16, no. 6, p. 413.

    Article  CAS  Google Scholar 

  23. Ye, S., Wang, C., Liu, X., et al., J. Contr. Rel., 2006, vol. 112, no. 1, p. 79.

    Article  CAS  Google Scholar 

  24. Balabushevich, N.G., Izumrudov, V.A., and Larionova, N.I., Vysokomol. Soedin., Ser. A, 2012, vol. 54, no. 7, pp. 1116–1129.

    Google Scholar 

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054, Russia

    M. S. Gurina, R. R. Vil’danova, L. A. Badykova, N. M. Vlasova & S. V. Kolesov

Authors
  1. M. S. Gurina
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  2. R. R. Vil’danova
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  3. L. A. Badykova
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  4. N. M. Vlasova
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  5. S. V. Kolesov
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Corresponding author

Correspondence to M. S. Gurina.

Additional information

Original Russian Text © M.S. Gurina, R.R. Vil’danova, L.A. Badykova, N.M. Vlasova, S.V. Kolesov, 2017, published in Zhurnal Prikladnoi Khimii, 2017, Vol. 90, No. 2, pp. 197−202.

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Gurina, M.S., Vil’danova, R.R., Badykova, L.A. et al. Microparticles based on chitosan–hyaluronic acid interpolyelectrolyte complex, which provide stability of aqueous dispersions. Russ J Appl Chem 90, 219–224 (2017). https://doi.org/10.1134/S1070427217020100

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  • DOI: https://doi.org/10.1134/S1070427217020100

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