Abstract
A copolymer of N,N-diallyl-N,N-dimethylammonium chloride with maleic acid of constant composition was prepared under the conditions of radical initiation. The possibility of the functionalization of the copolymer with drugs containing amino groups by polymer-analogous transformations was examined. Conditions were found for preparing conjugates of the copolymer with isoniazid. The structures and the quantitative compositions of the conjugates were determined by 13С NMR spectroscopy, and the possibility of preparing conjugates with controlled drug content was demonstrated.
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Original Russian Text © A.I. Vorob’eva, M.S. Babaev, L.V. Spirikhin, N.M. Shishlov, S.V. Kolesov, 2016, published in Zhurnal Prikladnoi Khimii, 2016, Vol. 89, No. 1, pp. 134−139.
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Vorob’eva, A.I., Babaev, M.S., Spirikhin, L.V. et al. Copolymer of N,N-diallyl-N,N-dimethylammonium chloride with maleic acid as drug carrier. Russ J Appl Chem 89, 160–164 (2016). https://doi.org/10.1134/S1070427216010250
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DOI: https://doi.org/10.1134/S1070427216010250