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Green synthesis of thiazol-2-ylthiazolidin-4-ones as potential antifungals

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Abstract

MORE (Microwave oriented reaction enhancement) green methodology was utilized to synthesize benzothiazol/thiazol-2-ylthiazolidin-4-ones and relatively assayed for their antifungal activity w.r.t precursors against three agriculturally important phytopathogenic fungi viz. Colletotrichum falcatum, Pyricularia grisea and Ustilago hordei. Thiazol-2-ylthiazolidin-4-ones displayed better inhibition of growth of fungi than their precursor’s thiazol-2-amines, with some compounds showing results comparable to their standard fungicides endorsing the effectiveness of chemical hybridization of thiazoles/benzothiazoles with thiazolidin-4-ones in a single molecule. In silico toxicity of all the compounds was found to be equivalent to the standard fungicides. Lipinski parameters were used to rationalize structure activity relation using statistical analysis software.

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Authors and Affiliations

  1. Department of Chemistry, Punjab Agricultural University, Ludhiana, 141004, India

    K. Gumber & A. Sidhu

  2. Department of Plant Pathology, Punjab Agricultural University, Ludhiana, 141004, India

    V. Kumar

Authors
  1. K. Gumber
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  2. A. Sidhu
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  3. V. Kumar
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Correspondence to K. Gumber.

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Gumber, K., Sidhu, A. & Kumar, V. Green synthesis of thiazol-2-ylthiazolidin-4-ones as potential antifungals. Russ J Appl Chem 88, 2065–2073 (2015). https://doi.org/10.1134/S10704272150120253

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