Skip to main content
SpringerLink
Log in

Modification of hyaluronic acid and chitosan, aimed at developing hydrogels for ophthalmology

  • Macromolecular Compounds and Polymeric Materials
  • Published:
Russian Journal of Applied Chemistry Aims and scope Submit manuscript

Abstract

Modification of hyaluronic acid and chitosan with the aim of preparing hydrogels based on them was performed. The formation of a covalent bond between mitomycin C and hyaluronic acid modified with epichlorohydrin was demonstrated. Hydrogels based on hyaluronic acid dialdehyde and chitosan modified with succinic anhydride were prepared. The degree of modification and concentration of the polymers influence the gelation process. Prolonged release of mitomycin C from the hydrogel obtained was revealed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Schante, C.E., Zuber, G., Herlin, C., and Vandamme, T.F., Carbohydrate Polym., 2011, vol. 85, no. 3, pp. 469–489.

    Article  CAS  Google Scholar 

  2. Zhang, L.M., Wu, C.-X., Huang, J.-Y., et al., Carbohydrate Polym., 2012, vol. 88, no. 4, pp. 1445–1452.

    Article  CAS  Google Scholar 

  3. Vercruysse, K.P. and Prestwich, G.D., Ther. Drug Carrier Syst., 1998, vol. 15, no. 5, pp. 513–555.

    CAS  Google Scholar 

  4. Lapcik, L., Jr. and Lapcik, L., Chem. Rev., 1998, vol. 98, no. 8, pp. 2663–2684.

    Article  CAS  Google Scholar 

  5. Burdick, J.A. and Prestwich, G.D., Adv. Mater., 2011, vol. 23, no. 12, pp. H41–H56.

    Article  CAS  Google Scholar 

  6. Tan, H. and Marra, K.G., Materials, 2010, vol. 3, no. 3, pp. 1746–1767.

    Article  CAS  Google Scholar 

  7. Khaw, P.T. and Midgal, C., Curr. Opin. Ophthalmol., 1996, vol. 7, no. 2, pp. 24–33.

    Article  CAS  Google Scholar 

  8. Shmyreva, V.F. and Mostovoi, E.N., Vestn. Oftal’mol., 2004, no. 3, pp. 7–10.

    Google Scholar 

  9. Kitazawa, Y., Kawaze, K., Matsushita, H., and Minobe, M., Arch. Ophtalmol., 1991, vol. 109, pp. 1693–1698.

    Article  CAS  Google Scholar 

  10. Yan, C., Chen, D., Gu, J., et al., Pharm. Soc. Jpn., 2006, vol. 126, pp. 789–793.

    CAS  Google Scholar 

  11. RF Patent 2215749, Publ. 2003.

  12. Simkovic, C., Hricovini, M., Soltes, L., et al., Carbohydrate Polym., 2000, vol. 41, pp. 9–14.

    Article  CAS  Google Scholar 

  13. Tan, H., Chu, C.R., Payne, K.A., and Marra, K.G., Biomaterials, 2009, vol. 30, pp. 2499–2506.

    Article  CAS  Google Scholar 

  14. Ruhela, D., Riviere, K., and Szoka, F.C., Bioconjugate Chem., 2006, vol. 17, no. 5l, pp. 1360–1363.

    Article  CAS  Google Scholar 

  15. Kuchina, Yu.A., Dolgopyatova, N.V., Novikov, V.Yu., et al., Vestn. Mosk. Gos. Tekh. Univ., 2012, vol. 15, no. 1, pp. 107–113.

    Google Scholar 

  16. Mura, C., Manconi, M., Valenti, D., et al., Carbohydrate Polym., 2011, vol. 85, no. 3, pp. 578–583.

    Article  CAS  Google Scholar 

  17. Gamzazade, A.I., Šlimak, V.M., Sklar, A.M., et al., Acta Polym., 1985, vol. 36, no. 8, p. 420.

    Article  CAS  Google Scholar 

  18. Hyaluronan, Kennedy, J.F., Phillips, G.O., Williams, P.A., and Hascall, V.C., Eds., Cambridge: Woodhead, 2002, vol. 2.

    Google Scholar 

  19. Lopatin, S.A., Nemtsev, S.V., and Varlamov, V.P., in Novye dostizheniya v issledovanii khitina i khitozana: Materialy VI Mezhdunarodnoi konferentsii (New Achievements in Studying Chitin and Chitosan: Proc. VI Int. Conf.), Moscow: Vseross. Nauchno-Issled. Inst. Rubnogo Khozyaistva i Okeanografii, 2001, pp. 298–299.

    Google Scholar 

  20. Beck, M.T. and Nagypal, I., Chemistry of Complex Equilibria, Budapest: Akad. Kiado, 1985.

    Google Scholar 

  21. Bulatov, M.N. and Kalinin, N.P., Prakticheskoe rukovodstvo po fotometricheskim metodam analiza (Practical Guide on Photometric Methods of Analysis), Leningrad: Khimiya, 1986.

    Google Scholar 

  22. Patent WO/2000/046253, Publ. 2000.

  23. Zhao, X.B., Fraser, J.E., Alexander, C., et al., J. Mater. Sci.: Mater. Med., 2002, vol. 13, no. 1, pp. 11–16.

    Google Scholar 

  24. Dahlmann, J., Krause, A., Moller, L., et al., Biomaterials, 2013, vol. 34, no. 4, pp. 940–951.

    Article  CAS  Google Scholar 

  25. Plate, N.A. and Vasil’ev, A.E., Fiziologicheski aktivnye veshchestva (Physiologically Active Compounds), Moscow: Khimiya, 1986.

    Google Scholar 

  26. Tomasz, M., Chowdary, D., Lipman, R., et al., Biochemistry, 1986, vol. 83, pp. 6702–6706.

    CAS  Google Scholar 

  27. Vasile, C., Pieptu, D., Dumitriu, R.P., et al., Rev. Med. Chir. Soc. Med. Nat., 2013, vol. 117, no. 2, pp. 565–571.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054, Russia

    R. R. Vil’danova, N. N. Sigaeva, V. P. Volodina, L. V. Spirikhin & S. V. Kolesov

  2. Bashkir State University, ul. Zaki Validi 32, Ufa, Bashkortostan, 450074, Russia

    O. S. Kukovinets

  3. Ufa Research Institute of Eye Diseases, Academy of Sciences of Bashkortostan Republic, ul. Pushkina 90, Ufa, Bashkortostan, 450077, Russia

    I. S. Zaidullin

Authors
  1. R. R. Vil’danova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. N. Sigaeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. S. Kukovinets
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. P. Volodina
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. V. Spirikhin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. I. S. Zaidullin
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S. V. Kolesov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to R. R. Vil’danova.

Additional information

Original Russian Text © R.R. Vil’danova, N.N. Sigaeva, O.S. Kukovinets, V.P. Volodina, L.V. Spirikhin, I.S. Zaidullin, S.V. Kolesov, 2014, published in Zhurnal Prikladnoi Khimii, 2014, Vol. 87, No. 10, pp. 1500–1511.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vil’danova, R.R., Sigaeva, N.N., Kukovinets, O.S. et al. Modification of hyaluronic acid and chitosan, aimed at developing hydrogels for ophthalmology. Russ J Appl Chem 87, 1547–1557 (2014). https://doi.org/10.1134/S1070427214100231

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070427214100231

Keywords

Search

Navigation