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Composite film materials based on poly(D,L-Lactide) and acexamic acid

  • Macromolecular Compounds and Polymeric Materials
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The influence of the hydrophilicity and molecular mass of poly(D,L-lactide) on the solubility of acexamic acid in the polylactide film and on the rate of its release from the polymer was studied. The release of acexamic acid from the polylactide film is described by a two-step model according to which the first step consists in dissolution of acexamic acid occurring in the intrinsic crystalline phase, and the second step, in the release of acexamic acid dissolved in the poly(D,L-lactide) phase. The results of conductometric measurements show that the limiting solubility of acexamic acid in poly(D,L-lactide) is higher in more hydrophilic films prepared using zinc lactate and amounts to 5–8%. The rate of the acexamic acid release increases with a decrease in the molecular mass of poly(D,L-lactide).

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  1. Biologicheski aktivnye perevyazochnye sredstva v kompleksnom lechenii gnoino-nekroticheskikh ran (Biologically Active Dressing Means in Complex Treatment of Purulent Necrotic Wounds), Fedorov, V.D., Ed., Moscow: Ministerstvo Zdravookhraneniya Ross. Federatsii, 2000.

    Google Scholar 

  2. Nazarenko, G.I., Sugurova, I.Yu., and Glyantsev, S.P., Rana. Povyazka. Bol’noi: Rukovodstvo dlya medsester (Wound. Dressing. Patient: Guide for Registered Nurses), Moscow: Meditsina, 2002.

    Google Scholar 

  3. Shtil’man, M.I., Soros. Obraz. Zh., 1998, no. 5, pp. 48–53.

    Google Scholar 

  4. Spravochnik lekarstv (Handbook of Drugs), , visited May 20, 2014.

  5. Gupta, A.P. and Vimal, K., Eur. Polym. J., 2007, vol. 43, pp. 4053–4074.

    Article  CAS  Google Scholar 

  6. Jerome, C. and Lecomte, P., Adv. Drug Delivery Rev., 2008, vol. 60, pp. 1056–1076.

    Article  CAS  Google Scholar 

  7. Schwach, G., Coudane, J., Engel, R., and Vert, M., Biomaterials, 2002, vol. 23, pp. 993–1002.

    Article  CAS  Google Scholar 

  8. Albertsson, A.C. and Varma, I.K., Biomacromolecules, 2003, vol. 4, pp. 1466–1486.

    Article  CAS  Google Scholar 

  9. Kaitian, X., Kozluca, A., Denkbas, E.B., and Piskin, E., Turk. J. Chem., 1996, vol. 20, no. 1, pp. 43–53.

    CAS  Google Scholar 

  10. Ma, D. and McHugh, A.J., Int. J. Pharm., 2010, vol. 388, pp. 1–12.

    Article  CAS  Google Scholar 

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Correspondence to Yu. A. Nashchekina.

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Original Russian Text © Yu.A. Nashchekina, I.M. Zorin, P.A. Fetin, S.Ya. Skachilova, A.Yu. Bilibin, 2014, published in Zhurnal Prikladnoi Khimii, 2014, Vol. 87, No. 8, pp. 1167–1171.

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Nashchekina, Y.A., Zorin, I.M., Fetin, P.A. et al. Composite film materials based on poly(D,L-Lactide) and acexamic acid. Russ J Appl Chem 87, 1146–1150 (2014).

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