Abstract
Procedure for encapsulation of rifampicin by evaporation of a volatile solvent was developed. An effective stabilizer making it possible to reach a 23% incorporation of the main substance into capsules was selected. The basic microcapsule parameters (particle size distribution, degree of polydispersity, and electrokinetic potential) were determined. The kinetics of rifampicin release from microcapsules was examined.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Cortesi, R., Menegatti, E., Nastruzzi, C., and Esposito, E., Modified-Release Drug Delivery Technology, Rathbone, M.J., Ed., New York: Marcel Dekker, 2003, pp. 453–461.
Garti, N. and Aserin, A., Microencapsulation: Methods and Industrial Applications: Benita, S., Ed., CRC Press, Taylor & Francis Group, 2006, 2nd ed., pp.345–429.
Bilati, U., Allémann, E., and Doelker, E., Eur. J. Pharmaceutics Biopharmaceutics, 2005, vol. 59, pp. 375–388.
Putney, S.D., Current Opinion in Chem. Biol., 1998, vol. 2, no. 4, pp. 548–552.
Bukar’, N.V., Krasnobaeva, S.T., Kienskaya, K.I., et al., Zh. Prikl. Khim., 2008, vol. 81, no. 2, pp. 286–290.
Penkina, Yu.A., Bukar’, N.V., Kienskaya, K.I., et al., Khim. Tekhnol., 2008, vol. 9, no. 5, pp. 217–220.
Chueshov, V.I., Promyshlennaya tekhnologiya lekarstv (Industrial Technology of Medicinals), Kharkov: NFAU, 2002.
Khlopov, D.S., Shvets, V.F., Kozlovskii, R.A., and Suchkov, Yu.P., Khim. Prom-st’ Segodnya, 2011, no. 4, pp. 12–17.
Tomoda, K. and Makino, K., Colloid Surfaces B: Biointerfaces, 2007, vol. 55, pp. 115–124.
Alex, R. and Bodmeier, R., J. Microencapsulation, 1990, vol. 7, no. 3, pp. 347–355.
Park, S.-J. and Kim, S.-H., J. Colloid Interface Sci., 2004, vol. 271, no. 2, pp. 336–341.
Takada, S., Yamagata, Y., Misaki, M., et al., J. Controlled Release, 2003, vol. 88, no. 2, pp.229–242.
Zhang, J.X. and Zhu, K.J., J. Microencapsulation, 2004, vol. 21, no. 7, pp. 775–785.
Cleland, J.L. and Jones, A.J.S., Pharmaceutical Res., 1996, vol. 13, no. 10, pp. 1464–1475.
Egorova, E.M., Revina, A.A., Rostovshikova, T.N., and Kiseleva, O.I., Vestn. Mosk. Gos. Univ., Ser. 2, Khim., 2001, vol. 42, no. 5, pp. 332–338.
Hasegawa, T., Hirota, K., Tomoda, K., et al., Colloids Surfaces B: Biointerfaces, 2007, vol. 60, pp. 221–228.
Kim, V., Bazhenov, A.V., Kienskaya, K.I., and Frolov, Yu.G., Vysokomol. Soedin., Ser. A, 1994, vol. 31, no. 1, pp. 95–107.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © M.V. Sardushkin, K.I. Kienskaya, E.V. Il’yushenko, G.V. Avramenko, 2013, published in Zhurnal Prikladnoi Khimii, 2013, Vol. 86, No. 5, pp. 835–839.
Rights and permissions
About this article
Cite this article
Sardushkin, M.V., Kienskaya, K.I., Il’yushenko, E.V. et al. Fabrication of rifampicin microcapsules with a polylactide shell. Russ J Appl Chem 86, 782–786 (2013). https://doi.org/10.1134/S1070427213050285
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1070427213050285