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The application of microfine ionites for the improvement of the efficiency of sorption processes in drug production (Review)

  • Technology of Organic and Inorganic Chemistry
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Abstract

Results of the application of microfine ionites of different classes for sorption methods in the production of versatile drugs are systemized. Kinetic and dynamic parameters of sorption isolation and chemical purification of drugs with participation of ion-exchanger of small graining are discussed; essential advantages of their application allowing intensification of ion-exchange technological processes of drugs production are determined. The review can be useful at elaboration of new sorption methods used for the production of the wide assortment of drugs and, first of all, antibiotics, enzymes, and vitamins.

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References

  1. Samsonov, G.V., Trostyanskaya, E.B., and El’kin, G.E., Ionnyi obmen. Sorbtsiya organicheskikh veshchestv (Ion Exchange. Sorption of Organic Compounds). Leningrad: Nauka, 1969.

    Google Scholar 

  2. Libinson, G.S., Fizikokhimicheskie svoistva karboksil’nykh kationitov (Physicochemical Properties of Carboxy Cation Exchanger), Moscow: Nauka, 1969.

    Google Scholar 

  3. Samsonov, G.V., Ion Exchange Sorption and Preparative Chromatography of Biologically Active Molecules, New York: Consultants Bureau Inc., 1986.

    Google Scholar 

  4. Helferich, F., Ion-exchange, New York: Mc Graw Hill, 1962.

    Google Scholar 

  5. Bogatyrev, V.L., Ionity v smeshannom sloe (Ion Exchangers in the Mixed Bed), Leningrad: Khimiya, 1968.

    Google Scholar 

  6. Mikrobnye fermenty i biotekhnologiya (Microbial Enzymes and Biotechnology), Fogarti, V.M., Ed., Moscow: Agropromizdat, 1986.

    Google Scholar 

  7. Ionity v khimicheskoi tekhnologii (Ion Exchangers in Chemical Engineering), Nikol’skii, B.P. and Romankov, P.G., Ed., Leningrad: Khimiya, 1982.

    Google Scholar 

  8. Samsonov, G.V., in Ionnyi obmen (Ion Exchange), Moscow: Nauka, 1981.

    Google Scholar 

  9. Kokotov, Yu.A., Ionity i ionnyi obmen (Ion Exchangers and Exchange), Leningrad: Khimiya, 1980.

    Google Scholar 

  10. Cherkasov, A.N., Pasechnik, V.A., Membrany i sorbenty v biotekhnologii (Membranes and Sorbents in Biotechnology), Leningrad: Khimiya, 1991.

    Google Scholar 

  11. Elinov, N.P., Osnovy biotekhnologii (Principles of Biotechnology), St-Petersburg: Nauka, 1995.

    Google Scholar 

  12. Gorshkov, V.I., Safronov, M.S., and Voskresenskii, N.M., Ionnyi obmen v protivotochnykh kolonnakh (Ion Exchange in Countercurrent Columns), Moscow: Nauka, 1981.

    Google Scholar 

  13. Viestur, U.E., Shmite, I.A., and Zhilevich, A.V., Biotekhnologiya. Biologicheskie agenty, tekhnologiya, apparatura (Biotechnology. Biological Agents, Technology, Equipment), Riga: Zinatne, 1987.

    Google Scholar 

  14. Volzhinskii, A.I. and Konstantinov, V.A., Regeneratsiya ionitov (Recovery of Ion Exchangers), Leningrad: Khimiya, 1990, 240 p.

    Google Scholar 

  15. Shataeva, L.K., Kuznetsova, N.N., and El’kin, G.E., Karboksil’nye kationity v biologii (Carboxy Ion Exchangers in Biology), Leningrad: Nauka, 1979.

    Google Scholar 

  16. Nogovitsyna, L.V., Mikhailov, V.A., Kharechko, A.T., and Sadovoi, N.V., Antibiotiki Khimioterapiya, 2004, vol. 49, no. 1. p. 47.

    Google Scholar 

  17. Ye, D., Xu, Z., and En, P., Sep. Sci. Tech., 2008, vol. 43, no. 6, pp. 1459–1473.

    Article  CAS  Google Scholar 

  18. Gangadharan, D., Nampoothiri, K.M., Sivaramakrishnan, S., and Pandey, A., Appl. Biochem. Biotechnol., 2009, vol. 158, no. 3, pp. 653–662.

    Article  CAS  Google Scholar 

  19. Samsonov, G.V., Sorbtsiya i khromatografiya antibiotikov (Sorption and Chromatography of Antibiotics), Moskva-Leningrad: Izd. Akad. Nauk SSSR, 1960, p. 4047.

    Google Scholar 

  20. Samuel’son, O., Ionoobmennye razdeleniya v analiticheskoi khimii (Ion Exchange Separation in Analytical Chemistry), Moscow: Khimiya, 1966.

    Google Scholar 

  21. Proizvodstvo antibiotikov (Antibiotics Manufacture), Navashina, S.M., Ed., Moscow: Meditsina, 1970.

    Google Scholar 

  22. Nikol’skii, B.P., In Neorganicheskie ionoobmennye materialy (Inorganic Ion Exchange Materials), Nikol’skii, B.P., Ed., Leningrad: Izd. Lenigrad. Gos. Univ., 1974.

    Google Scholar 

  23. Soldano, B.V, In Ionoobmennye smoly v meditsine i biologii (Ion Exchange Resins in Medicine and Biology), Kaplanskii, S.Ya., Ed., Moscow: Izd. Inostr. Lit., 1956.

    Google Scholar 

  24. Yurchenko, V.S., Kil’fin, G.I., Musabekov, K.B., Samsonov, G.V, et al., In Izbiratel’naya ioonoobmennaya sorbtsiya antibiotikov. Trudy Leningradsk. Khim. Farmatsevt. Inst. (Election Ion Exchange Sorption of Antibiotics. Proceedings of the Leningrad. Khim.Farmatsevt. Inst), 1968, no. 25. pp. 121–146.

  25. Smirnov, N.N., Volzhinskii, A.I., and Konstaninov, V.A., Raschet i modelirovanie ionoobmennykh reaktorov (Calculation and Simulation of Ion Exchange Reactors), Leningrad: Khimiya, 1984.

    Google Scholar 

  26. Belakhov, V.V. and Momot, N.N., In Ionnyi obmen i khromatografiya (Ion Exchange and Chromatography), Leningrad: Nauka, 1984. pp. 156–157.

    Google Scholar 

  27. Momot, N.N., Cand. Sci. (Chem.) Dissertation, Leningrad, 1972.

  28. Samsonov, G.V. and Momot, N.N., Dokl. Akad. Nauk SSSR, 1970, vol. 195, no. 4, pp. 903–905.

    CAS  Google Scholar 

  29. Momot, N.N., Kosheleva, I.A., and Samsonov, G.V., Antibiotiki, 1971, vol. 16, no. 9. pp. 793–796.

    CAS  Google Scholar 

  30. Samsonov, G.V. and Momot, N.N., Zh. Prikl. Khim., 1972, vol. 45, no. 6. pp. 1383–1385.

    CAS  Google Scholar 

  31. Samsonov, G.V. and Momot, N.N., Zh. Prikl. Khim., 1972, vol. 45, no. 6. pp. 1383–1385.

    CAS  Google Scholar 

  32. Samsonov, G.V. and Momot, N.N., In Ionnyi obmen (Ion Exchange), Leningrad: Nauka, 1970.

    Google Scholar 

  33. Samsonov, G.V. and Momot, N.N., Khim. Farm. Zh., 1972, vol. 6, no. 3. pp. 34–38.

    CAS  Google Scholar 

  34. Samsonov, G.V., Momot, N.N., and Dubinina, N.I., Zh. Prikl. Khim., 1973, vol. 46, no. 11. pp. 2436–2440.

    CAS  Google Scholar 

  35. Momot, N.N., Samsonov, G.V., and Dubinina, N.I., Zh. Prikl. Khim., 1974, vol. 47, no. 5. pp. 1162–1164.

    CAS  Google Scholar 

  36. Momot, N.N. and Samsonov, G.V., Zh. Prikl. Khim., 1974, vol. 47, no. 4. pp. 8478–50.

    Google Scholar 

  37. Momot, N.N. and Samsonov, G.V., Zh. Prikl. Khim., 1974, vol. 47, no. 4. pp. 917–919.

    CAS  Google Scholar 

  38. Momot, N.N., Samsonov, G.V., and Dubinina, N.I., Zh. Prikl. Khim., 1974, vol. 47, no. 6. pp. 1285–1288.

    CAS  Google Scholar 

  39. Vedeneeva, V.V., Dobrynina, O.V., Momot, N.N., and Samsonov, G.V., Khim. Farm. Zh., 1974, vol. 8, no. 2. pp. 52–55.

    CAS  Google Scholar 

  40. El’kin, G.E., Samsonov, G.V., Vorob’eva, V.Ya, et al., Zh. Fiz. Khim., 1976, vol. 50, no. 6. pp. 1562–1564.

    Google Scholar 

  41. El’kin, G.E., Lebedev, Yu.Ya., and Samsonov, G.V., Vysokomol. Soedin., 1975. Ser. A, vol. 17, no. 8. pp. 1870–1875.

    Google Scholar 

  42. Selezneva, A.A., El’kin, G.E., Samsonov, G.V, et al., Khim. Farm. Zh., 1977, vol. 11, no. 6. pp. 103–106.

    CAS  Google Scholar 

  43. Selezneva, A.A., El’kin, G.E., Luknitskaya, O.F, et al., Khim. Farm. Zh., 1977, vol. 11, no. 7. pp. 90–94.

    CAS  Google Scholar 

  44. Samsonov, G.V., El’kin, G.E., Lebedev, Yu.Ya., and Momot, N.N., In Ionity i ionnyi obmen (Ion Exchangers and Exchange), Leningrad: Nauka, 1975, pp. 98–102.

    Google Scholar 

  45. Rakutina, N.S., Momot, N.N., El’kin, G.E., and Samsonov, G.V., Khim. Farm. Zh., 1976, vol. 10, no. 6. pp. 94–97.

  46. Momot, N.N., Samsonov, G.V., and Rakutina, N.S., Khim. Farm. Zh., 1976, vol. 10, no. 9. pp. 88–91.

    CAS  Google Scholar 

  47. Kiseleva, E.M., Momot, N.N., Samsonov, G.V, et al., Prikl. Biokhim. Mikrobiol., 1977, vol. 13, no. 4. pp. 577–580.

    CAS  Google Scholar 

  48. Mirgorodskaya, O.A., Momot, N.N., Samsonov, G.V, et al., Prikl. Biokhim. Mikrobiol., 1977, vol. 13, no. 5. pp. 721–724.

    Google Scholar 

  49. Kiseleva, E.M., Momot, N.N., Samsonov, G.V, et al., Prikl. Biokhim. Mikrobiol., 1978, vol. 14, no. 5. pp. 730–734.

    CAS  Google Scholar 

  50. Selezneva, A.A., Grekova, V.K., Momot, N.N. et al., Khim. Farm. Zh., 1977, vol. 11, no. 10. pp. 2736.

    Google Scholar 

  51. Momot, N.N., Polyakov, O.N., Galynkin, V.A, et al., USSR Patent 659612, 1979; Chem. Abstr., 1979, vol. 91, 18357b.

    Google Scholar 

  52. Momot, N.N. and Belakhov, V.V., Zh. Prikl. Khim., 1988, vol. 61, no. 10. pp. 22802285.

    Google Scholar 

  53. El’kin, G.E., Yaskovich, G.A., Vorob’eva, V.Ya., and Samsonov, G.V., Khim. Farm. Zh., 1976, vol. 10, no. 1. pp. 22–26.

    Google Scholar 

  54. Yaskovich, G.A., El’kin, G.E., and Samsonov, G.V., Zh. Fiz. Khim., 1980, vol. 54, no. 5. pp. 1340–1341.

    CAS  Google Scholar 

  55. Lebedev, Yu.Ya., Gavryuchenkova, L.P., Momot, N.N, et al., Zh. Fiz. Khim., 1994, vol. 68, no. 10. pp. 1778–1781.

    CAS  Google Scholar 

  56. Belakhov, V.V., Momot, N.N., Kononov, V.N., and Samsonov, G.V., Zh. Prikl. Khim., 1981, vol. 54, no. 5. pp. 1164–1167.

    CAS  Google Scholar 

  57. Belakhov, V.V., Momot, N.N., Kononov, V.N., and Samsonov, G.V., Zh. Prikl. Khim., 1981, vol. 54, no. 6. pp. 1424–1426.

    CAS  Google Scholar 

  58. Belakhov, V.V. and Momot, N.N., Khim. Farm. Zh., 1982, vol. 16, no. 6. pp. 732–736.

    Google Scholar 

  59. Belakhov, V.V., Momot, N.N., Kononov, V.N., and Samsonov, G.V., Zh. Prikl. Khim., 1981, vol. 54, no. 7. pp. 1613–1614.

    CAS  Google Scholar 

  60. Belakhov, V.V. and Momot, N.N., Khim. Farm. Zh., 1983, vol. 17, no. 5. pp. 591593.

    Google Scholar 

  61. Belakhov, V.V. and Momot, N.N., Abstracts of Papers, Vserossiisk. konf. “Biomeditsinskaya inzheneriya i biotekhnologiya” (All-Russian Conf. on Biomedical Engineering and Biotechnology), Kursk, 2010. pp. 106–108.

  62. Belakhov, V.V. and Momot, N.N. Khim. Farm. Zh., 1984, vol. 18, no. 8. pp. 980–982.

    CAS  Google Scholar 

  63. Yaskovich, G.A., El’kin, G.E., Momot, N.N., and Samsonov, G.V., Khim. Farm. Zh., 1981, vol. 15, no. 1. pp. 86–89.

    CAS  Google Scholar 

  64. El’kin, G.E., Yaskovich, G.A., Momot, N.N., and Samsonov, G.V., Khim. Farm. Zh., 1981, vol. 15, no. 2. pp. 79–82.

    Google Scholar 

  65. Bogdanova, M.E. and Momot, N.N., Khim. Farm. Zh., 1986. T., 20, no. 2, pp. 201–204.

    CAS  Google Scholar 

  66. Bogdanova, M.E. and Momot, N.N., Antibiotiki Med. Biotekhnol., 1986, vol. 31, no. 11. pp. 845–847.

    CAS  Google Scholar 

  67. Bogdanova, M.E. and Momot, N.N., Zh. Prikl. Khim., 1986, vol. 59, no. 11. pp. 2601–2604.

    CAS  Google Scholar 

  68. Bogdanova, M.E. and Momot, N.N., Antibiotiki Med. Biotekhnol., 1987, vol. 32, no. 10. pp. 755–757.

    CAS  Google Scholar 

  69. Bogdanova, M.E., Momot, N.N., and Gerbauz, G.L., Zh. Prikl. Khim., 1987, vol. 60, no. 11. pp. 25872589.

    Google Scholar 

  70. Momot, N.N. and Bogdanova, M.E., Zh. Prikl. Khim., 1990, vol. 63, no. 12. pp. 2744–2751.

    CAS  Google Scholar 

  71. Kuznetsova, E.B., Bogdanova, M.E., Klyaus, L.T., and Momot, N.N., Zh. Prikl. Khim., 1991, vol. 64, no. 6. pp. 1246–1251.

    CAS  Google Scholar 

  72. Momot, N.N. and Bogdanova, M.E., Khim. Farm. Zh., 1994, vol. 28, no. 2. pp. 39–41.

    CAS  Google Scholar 

  73. Momot, N.N., Bogdanova, M.E., and Kochish, L.T., Khim. Farm. Zh., 1994, vol. 28, no. 2. pp. 41–44.

    CAS  Google Scholar 

  74. Aravina, L.A., Komarov, E.V., Momot, N.N, et al., RF Patent, 2175239, 2001, Chem. Abstr., 2001, vol. 137, 139714a.

    Google Scholar 

  75. Mishutkin, S.N. and Momot, N.N., Zh. Prikl. Khim., 2005, vol. 78, no. 11. pp. 1864–1867.

    Google Scholar 

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Authors and Affiliations

  1. Technion, Israel Technological Institute, Haifa, Izrael

    V. V. Belakhov

  2. St. Petersburg State Chemical Pharmaceutical Academy, St. Petersburg, Russia

    N. N. Momot

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  1. V. V. Belakhov
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Original Russian Text © V.V. Belakhov, N.N. Momot, 2010, published in Khimicheskaya Promyshlennost’, 2010, Vol. 87, No. 4, pp. 163–169.

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Belakhov, V.V., Momot, N.N. The application of microfine ionites for the improvement of the efficiency of sorption processes in drug production (Review). Russ J Appl Chem 83, 1683–1689 (2010). https://doi.org/10.1134/S1070427210090363

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