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Screening of Promising Biocatalysts for Enantioselective Reduction of Prochiral Carbonyl Compounds

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Abstract

The possibility of enantioselective biotransformation of a model prochiral carbonyl compound, acetophenone, by cellular catalysts based on a number of cultures of the Fabaceae family (Phaseolus vulgaris, Lens culinaris, Cicer arietinum, Vigna radiata, and Pisum sativum) was explored. According to the rate and direction of enantioselective bioreduction, enantioselectivity, and the yield of the target products, the most promising cellular catalysts for the asymmetric bioreduction of prochiral carbonyl compounds, which enable the synthesis of target alcohols of both (S)- and (R)-configurations, were identified.

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Funding

This work was supported by ongoing institutional funding. No additional grants to carry out or direct thisparticular research were obtained.

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Authors and Affiliations

  1. Ufa State Petroleum Technological University, 450062, Ufa, Russia

    A. R. Chanysheva, N. V. Privalov & V. V. Zorin

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  1. A. R. Chanysheva
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  2. N. V. Privalov
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  3. V. V. Zorin
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Correspondence to A. R. Chanysheva.

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Chanysheva, A.R., Privalov, N.V. & Zorin, V.V. Screening of Promising Biocatalysts for Enantioselective Reduction of Prochiral Carbonyl Compounds. Russ J Gen Chem 93, 3460–3463 (2023). https://doi.org/10.1134/S1070363223130285

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