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Electrochemical Synthesis of N-Substituted 5-(1H-Indol-3-yl)-1,3,4-oxadiazole-2-amines: A Mild and Green Approach

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Abstract

The work employs aliphatic and aromatic isothiocyanates and utilizes electrochemical techniques for the reaction. The process involves a two-electrode system with a conductive carbon working electrode and a counter electrode. An appropriate electrolyte, such as an organic solvent, is used, and upon applying an electric potential, electrochemical oxidation and nucleophilic substitution reactions occur, leading to the formation of the desired 1,3,4-oxadiazole-2-amines. Key advantages of this electrochemical method include its high functional group tolerance, enabling the synthesis of a wide range of compounds with different substituents. The reaction conditions can be fine-tuned for high conversion and selectivity, ensuring good overall yields of the target products. Additionally, the electrochemical method offers sustainability and convenience, making it a promising alternative to traditional synthesis. The use of electricity as an energy source is more environmentally friendly compared to traditional heating methods, contributing to greener and eco-friendly chemical processes.

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ACKNOWLEDGMENTS

The authors are thankful to the Pandit Deendayal Petroleum University, Ahmedabad, Gujarat, for providing the necessary laboratory facilities. Authors are also thankful to IIT Indore for providing necessary analytical facilities. Authors are also thankful for Dr. K.P. Patel, principal of Sir P T Science College Modasa, for his continuous assistance.

Funding

This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Department of Chemistry, Sir P T Science College Modasa, Hemchandracharya North Gujarat University, 383315, Patan, India

    Tarun M. Patel

  2. Department of Sciences, School of Technology, Pandit Deendayal Petroleum University, 382426, Gandhinagar, India

    Khushbu G. Patel

  3. Department of Chemistry, Shri C.N.P.F. Arts & D.N. Science College, 391110, Vadodara, India

    Parasar Modh

Authors
  1. Tarun M. Patel
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Correspondence to Khushbu G. Patel.

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Patel, T.M., Patel, K.G. & Modh, P. Electrochemical Synthesis of N-Substituted 5-(1H-Indol-3-yl)-1,3,4-oxadiazole-2-amines: A Mild and Green Approach. Russ J Gen Chem 93, 2948–2959 (2023). https://doi.org/10.1134/S1070363223110403

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