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Synthesis, Antibacterial, and Antimonooxidase Activity of 4-(2-Methyl-1,3-oxazol-5-yl)benzenesulfonamide

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Abstract

A new method for obtaining 4-(2-methyl-1,3-oxazol-5-yl)benzenesulfonamide, an antiglaucomatous drug candidate oxazopt, was developed using a diazotization reaction. A combined potentiated effect of the antimicrobial action of carbapenems (meropenem) and aminoglycosides (gentamicin) against antibiotic-resistant gram-positive bacteria Enterococcus faecium, Enterococcus faecalis and gram-negative bacteria Escherichia coli, and antimonooxidase effect in vitro was revealed for this compound.

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Funding

The synthesis and study of the antimonoamine oxidase activity of the compounds was carried out with the financial support of the Russian Science Foundation (grant No. 22-13-20085). The antibacterial properties and potentiation effects of the drug candidate oxazopt were carried out at the expense of the Ministry of Education (state assignment 073-00077-21-02 “Development of an innovative drug against glaucoma based on selective inhibition of carbonic anhydrase II,” registration number 730000F.99.1.BV10AA00006).

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Authors and Affiliations

  1. K.D. Ushinsky Yaroslavl State Pedagogical University, 150000, Yaroslavl, Russia

    O. A. Gasilina, A. A. Romanycheva, A. A. Shetnev & M. K. Korsakov

  2. Moscow Institute of Physics and Technology, 141700, Dolgoprudny, Russia

    A. A. Shetnev

  3. Kosygin Russian State University, 115035, Moscow, Russia

    O. A. Gasilina & M. K. Korsakov

Authors
  1. O. A. Gasilina
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  2. A. A. Romanycheva
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  3. A. A. Shetnev
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  4. M. K. Korsakov
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Correspondence to A. A. Shetnev.

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Gasilina, O.A., Romanycheva, A.A., Shetnev, A.A. et al. Synthesis, Antibacterial, and Antimonooxidase Activity of 4-(2-Methyl-1,3-oxazol-5-yl)benzenesulfonamide. Russ J Gen Chem 93, 2749–2755 (2023). https://doi.org/10.1134/S1070363223110038

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