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Synthesis, Antitubercular Evaluation, Molecular Docking Study, and Teratogenicity Studies of Novel Triazolo Quinazoline Hybrids

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Abstract

A novel series of triazole-quinazoline hybrid molecules was synthesized and characterized by spectral analyses. The H37 RV strain was used to test the newly synthesised compounds for antitubercular efficacy against Mycobacterium tuberculosis. Some of the synthesized compounds were effective compared with standard pyrazinamide at a concentration of 3.12 μg/mL. Additionally, molecular docking investigations were conducted on all synthesized compounds against the M. tuberculosis InhA protein, which is attenuated by the PT70 X-ray crystal structure, PDB ID: 2X22. Two compounds were revealed the best against 2X22, with Autodock scores of –9.13 and –8.59, respectively. To further investigate the teratogenicity of the synthesized compounds, zebrafish larvae were employed. At a concentration of 100 μM, some compounds showed no signs of abnormality.

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ACKNOWLEDGMENTS

The authors are thankful to G. Pulla Reddy college of Pharmacy, Hyderabad for providing necessary facilities to complete the research work.

Funding

This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, G. Pulla Reddy College of Pharmacy, Mehdipatnam, 500028, Hyderabad, India

    N. Raghavendra Babu & T. Radhika

  2. Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, 760010, Berhampur, India

    B. M. Sahoo

  3. Department of Pharmaceutical Chemistry, Akshaya Institute of Pharmacy, 572106, Tumkur, India

    B. Kumar C

  4. Department of Pharmaceutical Chemistry, KL College of Pharmacy, Koneru Lakshmaiah Educational Foundation, 522502, Vaddeswaram, India

    N. Malothu

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  1. N. Raghavendra Babu
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Correspondence to N. Raghavendra Babu.

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Babu, N.R., Sahoo, B.M., Radhika, T. et al. Synthesis, Antitubercular Evaluation, Molecular Docking Study, and Teratogenicity Studies of Novel Triazolo Quinazoline Hybrids. Russ J Gen Chem 93, 2684–2693 (2023). https://doi.org/10.1134/S1070363223100237

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