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Nano Au/TiO2 Catalyzed Click Synthesis of Novel 1,2,3-Triazoles from S-Propargyl-1,2,4-triazole: Antibacterial Activity, Toxicity, and Docking Analysis

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Abstract

A new series of 1,2,3-triazoles was synthesized by a titania-supported nano gold nanoparticles catalyzed 1,3-dipolar cycloaddition of aromatic azides with a 3-substituted 1,2,4-triazole terminal alkyne. The compounds were tested for antibacterial activity and antiradical efficiency. Further, in silico molecular docking studies were carried out against glucosamine-6-phosphate syntheses (PDB code: 2VF5) protein receptors. Toxicity of the compounds was studied through survival and climbing assays using an in vivo genetic model, Drosophila melanogaster.

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Funding

This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Department of Materials Science, Mangalore University, 574199, Mangalore, India

    V. Turukarabettu

  2. Department of Chemistry, Mangalore University, 574199, Mangalore, India

    B. Kalluraya

  3. Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), 575018, Mangalore, India

    P. Kumar & R. B. Chandrashekarappa

  4. Neurogenetics Lab, Department of Applied Zoology, Mangalore University, 574199, Mangalagangotri, India

    S. Varija Raghu

  5. Division of Neuroscience, Yenepoya Research Centre, Yenepoya (Deemed to be University), 575018, Mangalore, India

    S. Varija Raghu

Authors
  1. V. Turukarabettu
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  2. B. Kalluraya
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  3. P. Kumar
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  4. R. B. Chandrashekarappa
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  5. S. Varija Raghu
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Correspondence to V. Turukarabettu.

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Turukarabettu, V., Kalluraya, B., Kumar, P. et al. Nano Au/TiO2 Catalyzed Click Synthesis of Novel 1,2,3-Triazoles from S-Propargyl-1,2,4-triazole: Antibacterial Activity, Toxicity, and Docking Analysis. Russ J Gen Chem 93, 2638–2644 (2023). https://doi.org/10.1134/S1070363223100183

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