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Development of Spiro[chromane-2,4′-piperidine]-4(3H)-one Compounds in the Field of Medicinal Chemistry Research (A Review)

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Abstract

In the recent past, spiro[chromane-2,4′-piperidine]-4(3H)-one has been proven as one of the most valued scaffolds utilized by several medicinal chemists and pharmacologists to yield therapeutically effective biologicals. Spiro[chromane-2,4′-piperidine]-4(3H)-one is a member of the six-membered tricyclic molecule containing oxygen and nitrogen as hetero atoms. A spiro compounds is usually formed by the simultaneous reactions of condensation and cyclization. Owing to its versatile features, it has been incorporated in a wide variety of pharmaceuticals, bio-chemicals, sometimes even in the generation of hits as well as lead molecules. Chromanone-based spiro compounds have garnered a great deal of attention in recent years due to their presence in biologically active naturally derived compounds, such as vitamins, alkaloids, hormones, antibiotics, glycosides, and several other products. Compounds with the said backbone have shown their pharmacological potential as antidiabetic, anticancer, antioxidant, anti-inflammatory, anti-obesity, antihypertensive, antiplasmodial, antimalarial and antitumor. In addition to these, over the past few years, significant advancements in complex amido-piperidyl linked spiro heterocyclic chroman-4-ones have been continuously reported in pre-clinical and clinical investigations. This investigation highlights the remarkable development in the synthesis of spiro[chromane-2,4′-piperidine]-4(3H)-one-derived compounds over the past several years while focusing on the aspects of their therapeutical importance. In few cases plausible synthetic mechanism was also discussed.

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ACKNOWLEDGMENTS

Authors are thankful to Department of Pharmaceutical Chemistry, Gupta College of Technological Sciences Management, Asansol, Department of Chemical Engineering, National Chung Cheng University, Chia-Yi, Taiwan and Department of Chemistry, School of Advanced Science, VIT, Vellore for providing resources to write this review.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Gupta College of Technological Sciences, 713301, Asansol, India

    Sab. Banerjee & Sub. Banerjee

  2. Department of Pharmacology, Gupta College of Technological Sciences, 713301, Asansol, India

    U. Chakraborty & S. Banerjee

  3. Department of Chemical Engineering, National Chung Cheng University, 62102, Chia-Yi, Taiwan

    S. De

  4. Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, 632014, Vellore, India

    S. K. Ashok Kumar

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Banerjee, S., Banerjee, S., Chakraborty, U. et al. Development of Spiro[chromane-2,4′-piperidine]-4(3H)-one Compounds in the Field of Medicinal Chemistry Research (A Review). Russ J Gen Chem 93, 1274–1293 (2023). https://doi.org/10.1134/S1070363223050274

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