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A Practical Synthesis of 1-[3-(Trimethoxysilyl)propyl]-1H-imidazole

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Abstract

A simple and effective method for the synthesis of 1-[3-(trimethoxysilyl)propyl]-1H-imidazole was proposed by alkylation of sodium imidazolyl obtained from imidazole and sodium hydroxide with (3-chloropropyl)trimethoxysilane at reflux in toluene for 15 h. The target imidazole was obtained with a yield of 82%.

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Funding

The study was carried out as part of the governmental task of the Ministry of Education and Science of the Russian Federation (topic no. FZEN-2023-0006) using the equipment of the Center for Collective Use “Ecological Analytical Center” and the Scientific Educational Center “Diagnostics of the Structure and Properties of Nanomaterials” of the Kuban State University.

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Authors and Affiliations

  1. Kuban State University, 350040, Krasnodar, Russia

    N. A. El’kov, Dz. N. Konshina & V. V. Konshin

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  1. N. A. El’kov
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  2. Dz. N. Konshina
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  3. V. V. Konshin
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Correspondence to V. V. Konshin.

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El’kov, N.A., Konshina, D.N. & Konshin, V.V. A Practical Synthesis of 1-[3-(Trimethoxysilyl)propyl]-1H-imidazole. Russ J Gen Chem 93, 909–911 (2023). https://doi.org/10.1134/S1070363223040187

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  • DOI: https://doi.org/10.1134/S1070363223040187

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