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Synthesis, Structure, and Biological Activity of New Metal Carboxylate Complexes Containing a Glycoluril Fragment

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Abstract

Cu(II), Ni(II), Zn(II), Co(II), Fe(II), Mn(II) carboxylates containing a pharmacophoric glycoluril fragment were obtained for the first time. The proposed structure of the complexes was established using elemental analysis, spectral methods, and magnetochemistry. Structure of one of the copper(II) complexes was proved by X-ray diffraction analysis. Antibacterial and fungicidal activity of all the compounds was studied. It was shown that the starting acids are inactive, while some complexes exhibit antibacterial activity.

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ACKNOWLEDGMENTS

IR and NMR spectra were recorded at the Center for Collective Use “Molecular Spectroscopy” and the Educational and Scientific Laboratory of Resonance Spectroscopy of the Department of Chemistry of Natural and Macromolecular Compounds of the Southern Federal University.

Funding

X-ray diffraction studies were carried out using the scientific equipment of the Center for Research on the Structure of Molecules of the Institute of Organoelement Compounds. A.N. Nesmeyanov RAS with the support of the Ministry of Science and Higher Education of the Russian Federation as part of the governmental task (no. 075-03-2023-642).

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

    V. V. Baranov

  2. Southern Federal University, 344090, Rostov-on-Don, Russia

    N. I. Vikrishchuk

  3. North-Caucasian Zonal Research Veterinary Institute, 346406, Novocherkassk, Russia

    A. A. Zubenko & A. E. Svyatogorova

  4. Rostov State Transport University, 344038, Rostov-on-Don, Russia

    I. A. Estrin

  5. A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119334, Moscow, Russia

    E. S. Lipatov

  6. Higher Chemiсal College of the Russian Academy of Sciences, D.I. Mendeleev Russian University of Chemical Technology, 125047, Moscow, Russia

    E. S. Lipatov

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  1. V. V. Baranov
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  2. N. I. Vikrishchuk
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Correspondence to N. I. Vikrishchuk.

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Baranov, V.V., Vikrishchuk, N.I., Zubenko, A.A. et al. Synthesis, Structure, and Biological Activity of New Metal Carboxylate Complexes Containing a Glycoluril Fragment. Russ J Gen Chem 93, 863–869 (2023). https://doi.org/10.1134/S1070363223040126

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  • DOI: https://doi.org/10.1134/S1070363223040126

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