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Synthesis of Diethyl 6-Amino-1,4-diaryl-2-oxo-1,2,3,4-tetrahydropyridin-3,5-dicarboxylates Based on the Reaction of Arylmethylidenecyanoacetic Esters with N-Arylamidoesters of Malonic Acid

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Abstract

The reaction of arylmethylidenecyanoacetic esters with N-arylamides of malonic acid led to the formation of previously unknown diethyl 6-amino-1,4-diaryl-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxylates in 15–83% yields. Antibacterial activity of some obtained compounds was studied.

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Authors and Affiliations

  1. Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia, 0014, Yerevan, Armenia

    K. A. Avagyan, M. S. Sargsyan, A. E. Badasyan, A. A. Sargsyan, A. G. Manukyan, G. A. Panosyan, A. G. Ayvazyan & A. Kh. Khachatryan

  2. Crisis Management State Academy, 0040, Yerevan, Armenia

    A. Kh. Khachatryan

Authors
  1. K. A. Avagyan
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  2. M. S. Sargsyan
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  3. A. E. Badasyan
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  4. A. A. Sargsyan
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  5. A. G. Manukyan
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  6. G. A. Panosyan
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  7. A. G. Ayvazyan
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  8. A. Kh. Khachatryan
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Correspondence to A. Kh. Khachatryan.

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Avagyan, K.A., Sargsyan, M.S., Badasyan, A.E. et al. Synthesis of Diethyl 6-Amino-1,4-diaryl-2-oxo-1,2,3,4-tetrahydropyridin-3,5-dicarboxylates Based on the Reaction of Arylmethylidenecyanoacetic Esters with N-Arylamidoesters of Malonic Acid. Russ J Gen Chem 93, 787–794 (2023). https://doi.org/10.1134/S1070363223040035

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