Abstract
A new series of benzimidazoles including triazole and thiosemicarbazide moieties was synthesized and their urease inhibition studies were evaluated according to the method of Van Slyke and Archibald. Especially triazole derivatives have effective inhibition activities between 0.04±0.026 and 0.26±0.042 µM IC50 values. The best antiurease activities with IC50 0.04±0.026 and 0.06±0.033 µM belongs to 5-[(5,6-dichloro-1H-benzimidazol-1-yl)methyl]-4-nitrophenyl-4H-1,2,4-triazole-3-thiol and 2-[(2-benzyl-5,6-dichloro-1H-benzimidazol-1-yl)acetyl]-N-(4-nitrophenyl)hydrazinecarbothioamide, respectively.
REFERENCES
Kafarski, P. and Talma, M., J. Adv. Res., 2018, vol. 13, p. 101. https://doi.org/10.1016/j.jare.2018.01.007
Devesa, S.S., Blot, W.J., and Fraumeni, J.F., Cancer, 1998, vol. 83, p. 2049. https://doi.org/10.1002/(SICI)1097-0142(19981115)83:
Golbabaei, S., Bazl, R., Golestanian, S., Nabati, F., Omrany, Z.B., Yousefi, B., and Amanlou, M., DARU J. Pharm. Sci., 2013, vol. 21, p. 2. https://doi.org/10.1186/2008-2231-21-2
Menteşe, E., Akyüz, G., Emirik, M., and Baltaş, N., Bioorg. Chem., 2019, vol. 83, p. 289. https://doi.org/10.1016/j.bioorg.2018.10.031
Kosikowska, P. and Berlicki, Ł., Expert. Opin. Ther. Pat., 2011, vol. 21, p. 945. https://doi.org/10.1517/13543776.2011.574615
Valenzuela-Valderrama, M., Cerda-Opazo, P., Backert, S., González, M.F., Carrasco-Véliz, N., Jorquera-Cordero, C., Wehinger, S., Canales, J., Bravo, D., and Quest, A.F.G., Cancers, 2019, vol. 11, p. 799. https://doi.org/10.3390/cancers11060799
Mobley, H.L.T., Island, M.D., and Hausinger, R.P., Microbiol. Rev., 1995, vol. 59, p. 451. https://doi.org/10.1128/mr.59.3.451-480.1995
Ricc, A., Coppo, E., Barbieri, R., Debbia, E.A., and Marchese, A., J. Chemother., 2017, vol. 29, p. 67. https://doi.org/10.1080/1120009X.2016.1195069
Amtul, Z., Rahman, A.U., Siddiqui, R.A., and Choudhary, M., Curr. Med. Chem., 2002, vol. 14, p. 1323. https://doi.org/10.2174/0929867023369853
Follmer, C., J. Clin. Pathol., 2010, vol. 63, p. 424. https://doi.org/10.1136/jcp.2009.072595
Upadhyay, L.S.B., Ind. J. Biotechnol., 2012, vol. 11, p. 381.
Mentese, E., Emirik, M., and Sökmen, B.B., Bioorg. Chem, 2019, vol. 86, p. 151. https://doi.org/10.1016/j.bioorg.2019.01.061
Mentese, E., Bektaş, H., Sökmen, B.B., Emirik, M., Çakır, D., and Kahveci, B., Bioorg. Med. Chem. Lett., 2017, vol. 27, p. 3014. https://doi.org/10.1016/j.bmcl.2017.05.019
Salar, U., Nizamani, A., Arshad, F., Khan, K.M., Fakhri, M.I., Perveen, S., Ahmed, N., and Choudhary, M.I., Bioorg. Chem., 2019, vol. 91, p. 103170. https://doi.org/10.1016/j.bioorg.2019.103170
Karaali, N., Aydın, S., Baltaş, N., and Mentese, E., J. Heterocycl. Chem., 2020, vol. 57, p. 1806. https://doi.org/10.1002/jhet.3905
Baltaş, N., Yılmaz, F., and Mentese, E., Hacettepe J. Biol Chem, 2016, vol. 45, p. 293. https://doi.org/10.15671/HJBC.20164420572
Van Slyke, D.D. and Archibald, R.M., J. Biol. Chem., 1944, vol. 154, p. 623.
Pinner, A., Die Imidoäther und ihre Derivate, Berlin: Oppenheim, 1892.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
No conflict of interest was declared by the authors.
Rights and permissions
About this article
Cite this article
Akyüz, G., Menteşe, E. & Kahveci, B. Urease Inhibition Studies of New Benzimidazoles Containing Triazole Ring. Russ J Gen Chem 93, 449–454 (2023). https://doi.org/10.1134/S1070363223020287
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1070363223020287