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Design, Synthesis, and Preparation of Ultrasound-Responsive Curcumin-Loaded Chitosan Nanocarriers

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Abstract

In this study, chitosan was alkylated by o-nitrobenzyl to obtain liver-targeting and ultrasound-responsive functional materials. The Curcumin-loaded Chitosan nanoparticles were prepared by ion-crosslinking method. The encapsulation efficiency of the nanoparticles was about 89%, and the particle size of Curcumin-loaded Chitosan nanoparticles was about 520 nm. The in vitro drug release of curcumin from Curcumin-loaded Chitosan nanoparticles under ultrasound-free condition was very slow within 0–48 h, while the release of curcumin was very quick when the Curcumin-loaded Chitosan nanoparticles were stimulated by the ultrasound within 1–45 h. The ultrasound stimulation could cause a significant effect in promoting drug release from nanocarriers, indicating the broad application prospects of the on-demand released drug delivery systems.

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Funding

This research was funded by the National Innovation and Entrepreneurship Training Program for College Students (no. 202110593091), the National Natural Science Foundation of China (no. 21967003), and Guangxi Natural Science Foundation (2022GXNSFAA035453).

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Authors and Affiliations

  1. Medical College, Guangxi University, 530004, Nanning, China

    Ying Zhou, Shifu Li, Weiyan Tan, Xiufang Wei, Yi Chang, Qingyuan Yi & Jianyi Wang

  2. College of Life Science and Technology, Guangxi University, 530004, Nanning, China

    Chunxiao Pu

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  1. Ying Zhou
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  2. Shifu Li
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Correspondence to Jianyi Wang.

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Zhou, Y., Li, S., Tan, W. et al. Design, Synthesis, and Preparation of Ultrasound-Responsive Curcumin-Loaded Chitosan Nanocarriers. Russ J Gen Chem 93, 108–115 (2023). https://doi.org/10.1134/S1070363223010152

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