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Synthesis of 2-Heteroylidene Triterpenoids: Complex Formation with Palladium and in vitro Cytotoxic Activity

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Abstract

The interaction of palladium(II) chloride with 2-heteroylidene of betulonic acid (prepared via the condensation with pyridine-2-carbaldehyde, pyridine-3-carbaldehyde, pyridine-4-carbaldehyde, or quinoline-2-carbaldehyde) has been studied. Two ligands and one complex have been prepared for the first time; their structures have been confirmed by 2D NMR spectroscopy and high-resolution mass spectroscopy. The E-configuration of triterpenoid 2-heteroylidenes has been confirmed for the first time. Cytotoxic activity of the compounds with respect to the А549 cell line has been assessed.

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ACKNOWLEDGMENTS

The author acknowledges O.A. Maiorova (Perm Federal Research Center, Ural Branch, RAS) for recording the NMR spectra, I.A. Borisova (Perm Federal Research Center, Ural Branch, RAS) for recording the IR spectra, and Yu.A. Beloglazova (Perm Federal Research Center, Ural Branch, RAS) for performing the MTT test.

Funding

This study was performed in the scope of the State Task (the topic State Registration no. 122012400109-8). The work was carried out using the equipment of The Core Facilitied Center “Research of materials and matter” at the Perm Federal Research Center, Ural Branch, RAS.

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  1. Institute of Technical Chemistry of the Ural Branch of the Russian Academy of Sciences, Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences, 614013, Perm, Russia

    M. S. Denisov

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  1. M. S. Denisov
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Correspondence to M. S. Denisov.

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Denisov, M.S. Synthesis of 2-Heteroylidene Triterpenoids: Complex Formation with Palladium and in vitro Cytotoxic Activity. Russ J Gen Chem 93, 37–42 (2023). https://doi.org/10.1134/S1070363223010061

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  • DOI: https://doi.org/10.1134/S1070363223010061

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