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Biginelli Reaction in the Synthesis of Ethyl 4-(6-Aryl-5-benzoyl-4-hydroxy-2-thioxohexahydropyrimidine-4-carboxamido)benzoates

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Abstract

Three-component Biginelli reaction of ethyl 4-(2,4-dioxo-4-phenylbutanamido)benzoate, aromatic aldehyde and thiourea in acetic acid in the presence of sodium acetate led to the formation of ethyl 4-(6-aryl-5-benzoyl-4-hydroxy-2-thioxohexahydropyrimidine-4-carboxamido)benzoates. Structure of the obtained compounds was established by IR, 1H NMR, 13C spectroscopy methods.

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Funding

This work was financially supported by the Perm Scientific and Educational Center “Rational Subsoil Use,” 2022.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, 614990, Perm, Russia

    V. L. Gein, T. M. Zamaraeva & E. V. Gorgopina

  2. Perm State National Research University, 614990, Perm, Russia

    M. V. Dmitriev

Authors
  1. V. L. Gein
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  2. T. M. Zamaraeva
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  3. E. V. Gorgopina
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  4. M. V. Dmitriev
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Correspondence to V. L. Gein.

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Gein, V.L., Zamaraeva, T.M., Gorgopina, E.V. et al. Biginelli Reaction in the Synthesis of Ethyl 4-(6-Aryl-5-benzoyl-4-hydroxy-2-thioxohexahydropyrimidine-4-carboxamido)benzoates. Russ J Gen Chem 93, 16–21 (2023). https://doi.org/10.1134/S1070363223010036

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