Skip to main content
SpringerLink
Log in

Synthesis and Anti-MAO Activity of Acylation Products of Annelated Thiophene-2-amine and N-(5,5-Dimethyl-3-cyano-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-4-chlorobutanamide and Their Complexes with Cu(II), Zn(II), Ba(II), and Co(II)

  • Published:
Russian Journal of General Chemistry Aims and scope Submit manuscript

Abstract

Acylation of 2-amino-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carbonitrile and 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile with various acids chlorides in anhydrous dioxane furnished the corresponding amides. Coordination compounds were obtained by reacting copper(II) chloride, zinc(II), cobalt(II), and barium(II) acetates with N-(5,5-dimethyl-3-cyano-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-4-chlorobutanamide. Anti-MAO activity of the synthesized compounds was studied.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme
Scheme
Scheme
Fig. 1.

Similar content being viewed by others

REFERENCES

  1. Cetin, A., Türkan, F., Taslimi, P., and Gulçin, İ., J. Biochem. Mol. Toxicol., 2019, vol. 33, no. 3, p. e22261. https://doi.org/10.1002/jbt.22261

  2. Krivoshein, A.V., Curr. Pharm. Des., 2016, vol. 22, no. 32, p. 5029. https://doi.org/10.2174/138­16128­2266­6160­722­09­5748

    Article  CAS  Google Scholar 

  3. Semenov, V.V., Zolotareva, N.V., Domrachev, G.A., Bushuk, B.A., and Bushuk, S.B., Russ J Gen Chem., 2009, vol. 79, p. 2574. https://doi.org/10.1134/S1070363209120020

  4. Nemukhin, A.V., Grigorenko, B.L., and Granovskikh, A.A., Vestn. MGU, Ser. Khim., 2004, vol. 45, no. 2, p. 75.

    Google Scholar 

  5. Mashkovskii, M.D., Lekarstvennye sredstva (Drugs), Moscow: RIA “Novaya Volna”, 2010, p. 851.

  6. Akopyan, N.Z., Arutyunyan, N.S., Ovasyan, Z.A., Panosyan, G.A., Muradyan, R.E., Tumadzyan, A.E., and Gevorgyan, G.A., Khim. Zh. Armenii, 2021, vol. 74, nos. 1–2, p. 122.

    Google Scholar 

  7. Gor’kin, V.Z., Metody osnovannye na izmerenii osvobozhdaemogo ammiaka (Methods Based on the Measurement of Released Ammonia), Moscow: 1981, p. 34.

Download references

Author information

Authors and Affiliations

  1. Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 0014, Yerevan, Armenia

    A. U. Isakhanyan, N. Z. Hakobyan, A. S. Grigoryan, K. G. Navoyan, G. V. Gasparyan, R. P. Mkhitaryan, G. A. Panosyan & A. A. Harutyunyan

Authors
  1. A. U. Isakhanyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. Z. Hakobyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. S. Grigoryan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. G. Navoyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. V. Gasparyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R. P. Mkhitaryan
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. G. A. Panosyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. A. A. Harutyunyan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. U. Isakhanyan.

Ethics declarations

No conflict of interest was declared by the authors.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Isakhanyan, A.U., Hakobyan, N.Z., Grigoryan, A.S. et al. Synthesis and Anti-MAO Activity of Acylation Products of Annelated Thiophene-2-amine and N-(5,5-Dimethyl-3-cyano-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-4-chlorobutanamide and Their Complexes with Cu(II), Zn(II), Ba(II), and Co(II). Russ J Gen Chem 92, 2516–2520 (2022). https://doi.org/10.1134/S1070363222110391

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070363222110391

Keywords:

Search

Navigation