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Reactions of Tetramethyl Ethynyldiphosphonate with Substituted 2-Aminopyridines

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Abstract

The base-catalyzed hydroamination reaction of teramethyl ethynyldiphosphonate with substituted 2-aminopyridines was studied. The reaction proceeds stereoselectively with the formation of (E)-enaminophosphonates. A series of new phosphonoenamines, namely dimethyl [2-(dimethoxyphosphoryl)-2-(pyridin-2-ylamino)vinyl]phosphonates, was obtained.

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ACKNOWLEDGMENTS

The authors are grateful to A.V. Dogadina (St. Petersburg State Technological Institute (Technical University)) for providing ethynyldiphosphonic acid tetramethyl ester.

Funding

This work was financially supported by the Russian Foundation for Basic Research (project no. 0785.00.X6019) using the equipment of the Engineering Center of the St. Petersburg State Institute of Technology (Technical University).

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  1. St. Petersburg State Institute of Technology (Technical University), 190013, St. Petersburg, Russia

    K. N. Dakuo, A. S. Krylov & N. I. Svintsitskaya

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  1. K. N. Dakuo
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  2. A. S. Krylov
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  3. N. I. Svintsitskaya
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Correspondence to N. I. Svintsitskaya.

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N.I. Svintsitskaya is a member of the Editorial Board of the Journal of General Chemistry. The other authors declare no conflicts of interest.

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Dakuo, K.N., Krylov, A.S. & Svintsitskaya, N.I. Reactions of Tetramethyl Ethynyldiphosphonate with Substituted 2-Aminopyridines. Russ J Gen Chem 92, 2267–2272 (2022). https://doi.org/10.1134/S107036322211010X

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  • DOI: https://doi.org/10.1134/S107036322211010X

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