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Biscarbazole Derivatives: Synthesis, Characterization, Antimicrobial and Antitumor Activity, and Molecular Docking Study

Russian Journal of General Chemistry volume 92, pages 2145–2160 (2022)Cite this article

Abstract

New series of biscarbazole derivatives containing imine-amine groups was synthesized. Antimicrobial activity of newly synthesized compounds against bacterial strains and yeast isolates was determined. The effects of the synthesized test compounds on cell proliferation and NCI-60 survival parameter values were measured. In addition, in silico analysis against five different receptors with synthesized two compounds was carried out to see the necessary interactions responsible for anti-bacterial activity. The docking results of both compounds supported the antibacterial activity exhibiting high inhibition constants.

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ACKNOWLEDGMENTS

This work was supported by the Scientific research Project of Karadeniz Technical University (grant no. FBS-2021-9685).

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, Karadeniz Technical University, 61080, Trabzon, Turkey

    F. Çelik & Y. Ünver

  2. Department of Basic Medical Science, Faculty of Medicine, Bozok University, 66100, Yozgat, Turkey

    A. Aydın

  3. Department of Molecular Biology and Genetics, Karadeniz Technical University Faculty of Science, 61080, Trabzon, Turkey

    K. İ. Bektaş, H. İ. Güler & A. Nalçaoğlu

Authors
  1. F. Çelik
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  2. A. Aydın
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  3. K. İ. Bektaş
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Correspondence to Y. Ünver.

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Çelik, F., Aydın, A., Bektaş, K.İ. et al. Biscarbazole Derivatives: Synthesis, Characterization, Antimicrobial and Antitumor Activity, and Molecular Docking Study. Russ J Gen Chem 92, 2145–2160 (2022). https://doi.org/10.1134/S1070363222100279

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  • DOI: https://doi.org/10.1134/S1070363222100279

Keywords:

  • carbazole
  • amine
  • imine
  • antimicrobial activity
  • antitumor activity
  • docking study