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Reaction of 5-Aryl-4-hetaroyl-3-hydroxy-1-hydroxyethyl-1,5-dihydro-2H-pyrrol-2-ones with Nucleophilic Agents

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Abstract

The reaction of 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyethyl-1,5-dihydro-2H-pyrrol-2-ones with p-toluidine proceeds at the carbonyl group in the side chain at the C4 atom of the heterocycle to form 5-aryl-4-[2-hetaryl(4-methylphenylamino)methylidene]-1-hydroxyethylpyrrolidine-2,3-diones. The reaction of 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyethyl-1,5-dihydro-2H-pyrrol-2-ones with hydrazine hydrate affords dihydro- and tetrahydropyrrolo[3,4-c]pyrazoles.

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Funding

This work was financially supported by the Perm Scientific and Educational Center “Rational Subsoil Use,” 2022.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, 614990, Perm, Russia

    V. L. Gein, D. D. Rubtsova & A. A. Gagarina

  2. E. A. Vagner Perm State Medical University, 614990, Perm, Russia

    L. F. Gein

  3. Perm State National Research University, 614068, Perm, Russia

    M. V. Dmitriev

Authors
  1. V. L. Gein
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  2. D. D. Rubtsova
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  3. A. A. Gagarina
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  4. L. F. Gein
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  5. M. V. Dmitriev
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Correspondence to V. L. Gein.

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Gein, V.L., Rubtsova, D.D., Gagarina, A.A. et al. Reaction of 5-Aryl-4-hetaroyl-3-hydroxy-1-hydroxyethyl-1,5-dihydro-2H-pyrrol-2-ones with Nucleophilic Agents. Russ J Gen Chem 92, 1585–1590 (2022). https://doi.org/10.1134/S1070363222090018

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