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Synthesis of 1-(4-Alkoxybenzyl)-1H-(benz)imidazoles

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Abstract

N-Alkylation of 1H-imidazole and 1H-benzimidazole with 4-n-octyloxybenzylchloride, 4-n-hexadecyloxybenzylchloride and 1-(adamantyl-1)-2-[4-(hydroxymethyl)phenoxy]ethanone was considered as an alternative to O-alkylation of 4-[(1Н-imidazol-1-yl)methyl]phenol and 4-[(1Н-benzimidazol-1-yl)methyl]phenol with n-octylbromide, n-hexadecylbromide and (adamantyl-1)bromomethylketone. Additionally, the efficiency of two methods was compared based on total yields of target reaction products.

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Authors and Affiliations

  1. Institute of Natural Sciences, S. P. Korolev Samara National Research University, 443086, Samara, Russia

    A. V. Basantcev, A. A. Danilin & P. P. Purygin

  2. Togliatti State University, 445020, Togliatti, Russia

    A. A. Golovanov

Authors
  1. A. V. Basantcev
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  2. A. A. Danilin
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  3. A. A. Golovanov
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  4. P. P. Purygin
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Correspondence to A. V. Basantcev.

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Basantcev, A.V., Danilin, A.A., Golovanov, A.A. et al. Synthesis of 1-(4-Alkoxybenzyl)-1H-(benz)imidazoles. Russ J Gen Chem 92, 1280–1284 (2022). https://doi.org/10.1134/S1070363222070167

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  • DOI: https://doi.org/10.1134/S1070363222070167

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