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One-Pot Pseudo-Five-Component Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives via [DBU][OAc] as Ionic Liquid, and Their Anti-Cancer Evaluation and Molecular Modelling

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Abstract

Synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives in the presence of eco-friendly ionic liquid [DBU][OAc] via a one-pot three-component environmentally benign reaction has been carried out. The multi-component reaction proceeds with initial formation of an isatoic anhydride from aromatic aldehydes and aromatic amines in [DBU][OAc] as ionic liquid medium at 70–75°C with 85–90% yield. The products have been tested for cell viability against A549 and PC-3 cell lines. Among the tested products, compounds 4d and 4f demonstrate efficient cell toxicity. The target protein and ligand interactions have been modelled by molecular docking using AutoDockTools.

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ACKNOWLEDGMENTS

Authors Kulkarni Kalpana,and B. Ravi Kirana are very thankful to the authorities of GRIET for providing research facilities.

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Authors and Affiliations

  1. Department of Humanities and Sciences (Chemistry), Gokaraju Rangaraju Institute of Engineering and Technology, Bachupally, 500090, Hyderabad, India

    Kulkarni Kalpana & B. Ravi Kiran

  2. Department of Chemistry, Institute of Aeronautical Engineering, Dundigal, 500043, Hyderabad, India

    V. Anitha Rani

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  1. Kulkarni Kalpana
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  2. V. Anitha Rani
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  3. B. Ravi Kiran
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Correspondence to Kulkarni Kalpana.

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Kalpana, K., Rani, V.A. & Kiran, B.R. One-Pot Pseudo-Five-Component Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives via [DBU][OAc] as Ionic Liquid, and Their Anti-Cancer Evaluation and Molecular Modelling. Russ J Gen Chem 92, 1070–1075 (2022). https://doi.org/10.1134/S1070363222060196

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