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Synthesis and Anti-MAO Activity of Alkylation Products of 2-Aminobenzamide, 2-Amino-1-(4-nitrophenyl)propane-1,3-diol, and Some Amino Acids with Mono- and Bis-β-aminoketones

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Abstract

Reactions of substituted 3-(diethylamino)propan-1-ones hydrochlorides with 2-aminobenzamide, 2-amino-1-(4-nitrophenyl)propane-1,3-diol and some amino acids afforded the corresponding β-amino-ketones. 2,2′-{1,ω-alkane-diylbis[oxy-4,1-phenylene(3-oxo-3,1-propanediyl)imino]}bisbenzamides were synthesized in the same way. Anti-MAO activity of the synthesized compounds was studied.

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Authors and Affiliations

  1. Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, 0014, Yerevan, Armenia

    N. Z. Akopyan, A. G. Agababyan, Z. A. Ovasyan, A. U. Isakhanyan, A. S. Grigoryan, K. G. Navoyan, G. V. Gasparyan & H. A. Panosyan

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  1. N. Z. Akopyan
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  2. A. G. Agababyan
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  3. Z. A. Ovasyan
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  4. A. U. Isakhanyan
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  5. A. S. Grigoryan
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  6. K. G. Navoyan
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  7. G. V. Gasparyan
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  8. H. A. Panosyan
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Correspondence to A. G. Agababyan.

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Akopyan, N.Z., Agababyan, A.G., Ovasyan, Z.A. et al. Synthesis and Anti-MAO Activity of Alkylation Products of 2-Aminobenzamide, 2-Amino-1-(4-nitrophenyl)propane-1,3-diol, and Some Amino Acids with Mono- and Bis-β-aminoketones. Russ J Gen Chem 92, 925–931 (2022). https://doi.org/10.1134/S1070363222060019

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  • DOI: https://doi.org/10.1134/S1070363222060019

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