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Synthesis, Alpha-Glucosidase Inhibition and Antibacterial Activities of the New Chiral (R)-3,3′-Disubstituted BINOL-Phosphates

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Abstract

A new class of 3,3′-disubstituted chiral (R)-BINOL-derived phosphoric acid derivatives has been prepared. The synthetic method has been optimized by involving Pd/C as a catalyst in the Suzuki–Miyaura cross coupling using a non-protected BINOL derivative. The target compounds have been characterized and tested for their α-glucosidase inhibitory and antibacterial activities.

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ACKNOWLEDGMENTS

We acknowledge the Department of Science and Technology (DST) (DST-SERB-ECR/2016/000288) India for providing the financial assistance and Gandhi Institute of Technology (GITAM) University for providing the facility. We would like to thank Prof. G.A.Rama Rao, Principal SoS, (GITAM), for his valuable suggestions while preparing the manuscript.

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Authors and Affiliations

  1. Department of Chemistry, Jawaharlal Nehru Technological University, Hyderabad, 500085, Telangana, India

    Yesuraju Konda & Aparna Pasula

  2. Department of Chemistry, GITAM Deemed to be University, Hyderabad, 502329, Telangana, India

    Ashok Reddy Ankireddy, Vani Madhuri Velavalapalli & Rambabu Gundla

  3. Department of Chemistry, KG Reddy College of Engineering and Technology, Hyderabad, 501504, Telangana, India

    Kalyani Paidikondala

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  1. Yesuraju Konda
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  2. Ashok Reddy Ankireddy
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  3. Vani Madhuri Velavalapalli
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  4. Kalyani Paidikondala
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  5. Aparna Pasula
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  6. Rambabu Gundla
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Correspondence to Aparna Pasula or Rambabu Gundla.

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Konda, Y., Ankireddy, A.R., Velavalapalli, V.M. et al. Synthesis, Alpha-Glucosidase Inhibition and Antibacterial Activities of the New Chiral (R)-3,3′-Disubstituted BINOL-Phosphates. Russ J Gen Chem 92, 898–907 (2022). https://doi.org/10.1134/S1070363222050206

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