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Synthesis and Cytotoxic Activity of Tetrazole-Containing 1,5,6,7-Tetrahydro-4H-indazol-4-ones

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Abstract

Tetrazole-containing 1,5,6,7-tetrahydro-4H-indazol-4-ones were synthesized by condensation of 2-(tetrazolylacetyl)cyclohexane-1,3-diones with phenyl- or 4-fluorophenylhydrazines in ethanol at room temperature. Structure of the synthesized compounds were confirmed by 1H, 13C, 19F NMR spectroscopy methods. Cytotoxic activity of the series of obtained compounds was investigated in vitro against human laryngeal cancer cells Hep2.

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Funding

This work was supported by the Belarusian Republican Foundation for Basic Research (project X20R-226) and the Russian Foundation for Basic Research (project 20-53-00039-Bel_a) using the equipment of the Center for Collective Use “Proteomic Analysis” with the support of the Ministry of Education and Science of Russia (agreement no. 075-15-2021-691).

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Authors and Affiliations

  1. Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, 220141, Minsk, Belarus

    T. S. Khlebniсova, V. G. Zinovich, Yu. A. Piven, A. V. Baranovsky & F. A. Lakhvich

  2. St. Petersburg State Institute of Technology (Technical University), 190013, St. Petersburg, Russia

    R. E. Trifonov

  3. A. V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090, Novosibirsk, Russia

    Yu. A. Golubeva & E. V. Lider

  4. Institute of Molecular Biology and Biophysics – Subdivision of the Federal Research Center for Fundamental and Translational Medicine, 630060, Novosibirsk, Russia

    Yu. A. Golubeva

Authors
  1. T. S. Khlebniсova
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  2. V. G. Zinovich
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  3. Yu. A. Piven
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  4. A. V. Baranovsky
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  5. F. A. Lakhvich
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  6. R. E. Trifonov
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  7. Yu. A. Golubeva
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  8. E. V. Lider
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Correspondence to T. S. Khlebniсova.

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Khlebniсova, T.S., Zinovich, V.G., Piven, Y.A. et al. Synthesis and Cytotoxic Activity of Tetrazole-Containing 1,5,6,7-Tetrahydro-4H-indazol-4-ones. Russ J Gen Chem 92, 359–366 (2022). https://doi.org/10.1134/S1070363222030045

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