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7-Aryl-3-(hydroxymethyl)-5-oxo-1,2,3,5-tetrahydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitriles: Synthesis and Predicted Biological Activity

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Abstract

Aminomethylation of 1,6-diamino-4-aryl-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles under the action of excess of formaldehyde in ethanol has led to the formation of 7-aryl-3-(hydroxymethyl)-5-oxo-1,2,3,5-tetrahydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitriles. Bioavailability parameters of the obtained compounds have been predicted in silico and the possible protein targets have been predicted via the protein-ligand docking.

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ACKNOWLEDGMENTS

This study was performed using the equipment of the “Diagnostics of Structure and Properties of Nanomaterials” Research and Educational Center as well as Ecological and Analytical Center, Kuban State University.

Funding

This study was financially supported by the Russian Foundation for Basic Research and the Administration of Krasnodar Region (project no. 20-43-235002 “r_Nastavnik_Krasnodar”) as well as Ministry of Education and Science of the Russian Federation (topic 0795-2020-0031).

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  1. Kuban State University, 350040, Krasnodar, Russia

    A. A. Dolganov, A. G. Levchenko, P. G. Dahno, D. D. Guz’, A. R. Chikava & V. V. Dotsenko

  2. North Caucasus Federal University, 355009, Stavropol, Russia

    V. V. Dotsenko, N. A. Aksenov & I. V. Aksenova

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  1. A. A. Dolganov
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Correspondence to V. V. Dotsenko.

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Dolganov, A.A., Levchenko, A.G., Dahno, P.G. et al. 7-Aryl-3-(hydroxymethyl)-5-oxo-1,2,3,5-tetrahydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitriles: Synthesis and Predicted Biological Activity. Russ J Gen Chem 92, 185–197 (2022). https://doi.org/10.1134/S1070363222020074

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