Abstract
A series of novel 1,2,3-triazoles (8a–8m) were synthesized using click chemistry in excellent yields and were characterized by IR, NMR, MASS spectroscopy and elemental analysis. The final compounds 8a–8m were assessed for their antifungal activity. Among the compounds tested 8h, 8i, 8b, and 8e demonstrated potent antifungal activity where as compounds 8j, 8d, 8l, and 8f were exhibited good antifungal activity against tested fungal strains compared to the reference drug Nystatin.
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ACKNOWLEDGMENTS
A. Kishore Kumar is grateful to IQAC and Principal Vardhaman College of Engineering, Hyderabad, Telangana, India for support and CFRD, Osmania University, Hyderabad, India for providing analytical support. V. Sunitha thanks the Head of the Department, and Principal, UCSS, Osmania University, Hyderabad and Secretary, TSWREIS for support.
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Kumar, A.K., Sunitha, V., Ramesh, G. et al. Development of New Molecular Entities as Potent Antifungal Agents: Synthesis of Substituted 1,2,3-Triazoles. Russ J Gen Chem 91, 2546–2553 (2021). https://doi.org/10.1134/S1070363221120264
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DOI: https://doi.org/10.1134/S1070363221120264