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Synthesis and Cytotoxic Studies of Quinazoline-Triazole Hybrid Aza Heterocycles

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Abstract

Herein, we report a series of 1,2,3-triazole combined with quinazoline hybrid heterocyclic compounds by 1,3-dipolar cycloaddition reaction catalyzed by Cu(I). This reaction has been carried out between quinazoline based alkyne and aryl/benzyl azides under optimized conditions. Modification of 4-hydroxyquinazoline by propargyl bromide in presence of potassium carbonate gives a corresponding alkyne. Structure of the synthesized compounds has been characterized by IR, 1H, and 13C NMR, ESI-Mass, and HRMS spectra. The products have been tested for anticancer activity against C6 glioma cell lines and characterized by moderate cytotoxic activity.

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ACKNOWLEDGMENTS

VS is grateful to Department of Chemistry, Osmania University for providing research facilities. The authors express their gratitude and thanks to the CFRD, Osmania University, for providing NMR facility. The authors are thankful to OU SAP, DST-PURSE-II, DST-FIST programme for the financial assistance.

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Authors and Affiliations

  1. Department of Chemistry, University College of Science, Saifabad, Osmania University, 500004, Hyderabad, India

    Sumathi Vodnala

  2. Department of Chemistry, Osmania University, 500007, Hyderabad, India

    Anagani Kanaka Durga Bhavani, Shankaraiah Pagilla, Muralidhar Allam & Nagamani Rayala

  3. Department of Biotechnology, School of Life Sciences, University of Hyderabad, 500046, Hyderabad, India

    Anwita Mudiraj & Phanithi Prakash Babu

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  1. Sumathi Vodnala
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  2. Anagani Kanaka Durga Bhavani
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Correspondence to Anagani Kanaka Durga Bhavani.

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Vodnala, S., Bhavani, A.K.D., Pagilla, S. et al. Synthesis and Cytotoxic Studies of Quinazoline-Triazole Hybrid Aza Heterocycles. Russ J Gen Chem 91, 2304–2310 (2021). https://doi.org/10.1134/S1070363221110189

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