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Synthesis of Ethyl 3-Methyl-4,5-dioxo-1,2-diphenylpyrrolidine-3-carboxylate Analogues Using Green and Expeditious Grinding Method

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Abstract

A specific efficient method of synthesis of biologically active analogues of the title compound from acetylene dicarboxylate, aniline and various aromatic aldehydes catalyzed by citric acid by one-pot mortar-pestle grinding is described. The short time synthesis is characterized by high yields and comparable with the similar mechano-chemical process of planetary ball-milling. Easy isolation of the products without involving separation methods makes this green synthesis to be cost-efficient.

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Funding

The authors thanks Ministry of Higher Education for the financial support (600-IRMI/FRGS 5/3 (398/2019).

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Authors and Affiliations

  1. Organic Synthesis Research Laboratory, Institute of Science (I.O.S), Universiti Teknologi MARA, Bandar Puncak Alam, 42300, Selangor, Malaysia

    M. F. Mohammat, F. N. A. Abdul Rashid, Z. Shaameri & A. S. Hamzah

  2. Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, 40450, Selangor, Malaysia

    U. Safyudin

  3. Faculty of Mechanical Engineering, Universiti Teknologi PETRONAS, Seri Iskandar, 32610, Perak, Malaysia

    S. N. Md. Salleh

  4. ntimicrobial Laboratory, Anti-Infective Branch, Bioactivity Programme, Natural Products Division, Forest Research Institute Malaysia (FRIM), Kepong, 52109, Selangor, Malaysia

    S. A. Johari

Authors
  1. M. F. Mohammat
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  2. U. Safyudin
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  3. F. N. A. Abdul Rashid
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  4. S. N. Md. Salleh
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  5. S. A. Johari
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  6. Z. Shaameri
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  7. A. S. Hamzah
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Correspondence to M. F. Mohammat.

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Mohammat, M.F., Safyudin, U., Rashid, F.N.A.A. et al. Synthesis of Ethyl 3-Methyl-4,5-dioxo-1,2-diphenylpyrrolidine-3-carboxylate Analogues Using Green and Expeditious Grinding Method. Russ J Gen Chem 91, 2272–2279 (2021). https://doi.org/10.1134/S1070363221110141

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  • DOI: https://doi.org/10.1134/S1070363221110141

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