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Synthesis of New 2-Aryl-4-[1,2-bis(dialkoxyphosphoryl)vinyl]-5-ethoxy-1,3-oxazoles

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Abstract

A series of new substituted phosphonylated 1,3-oxazoles, 2-aryl-4-[1,2-bis(dialkoxyphosphoryl)vinyl]-5-ethoxy-1,3-oxazoles, was obtained by the reaction of ethynyldiphosphonic acid tetramethyl ester with diethyl 2-aroylaminomalonates. The reaction proceeds stereoselectively with the intermediate formation of the corresponding Z-2-aroylamino-2-[1,2-bis(dialkoxyphosphoryl)vinyl]malonates.

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ACKNOWLEDGMENTS

The authors are grateful to N.B. Viktorov (St. Petersburg State Institute of Technology) for providing diethyl 2-aroylaminomalonates.

Funding

This work was financially supported by the Russian Foundation for Basic Research (project no. 19-03-00365_A) using the equipment of the Engineering Center of the St. Petersburg State Institute of Technology (Technical University).

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Authors and Affiliations

  1. St. Petersburg State Institute of Technology (Technical University), 190013, St. Petersburg, Russia

    P. A. Zhuravleva, A. I. Kolina, N. I. Svintsitskaya & A. V. Dogadina

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  1. P. A. Zhuravleva
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  2. A. I. Kolina
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  3. N. I. Svintsitskaya
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Correspondence to N. I. Svintsitskaya.

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N.I. Svintsitskaya is a member of the Editorial Board of the Russian Journal of General Chemistry. No conflict of interest was declared by the other authors.

Additional information

Translated from Zhurnal Obshchei Khimii, 2021, Vol. 91, No. 10, pp. 1594–1600 https://doi.org/10.31857/S0044460X21100164.

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Zhuravleva, P.A., Kolina, A.I., Svintsitskaya, N.I. et al. Synthesis of New 2-Aryl-4-[1,2-bis(dialkoxyphosphoryl)vinyl]-5-ethoxy-1,3-oxazoles. Russ J Gen Chem 91, 2031–2037 (2021). https://doi.org/10.1134/S1070363221100169

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