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Hydrolysis of Substituted 3-(Thien-2-yl)imino-3H-furan-2-ones and Anti-Inflammatory Activity of the Reaction Products

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Abstract

The hydrolysis of substituted 3-(thien-2-yl)imino-3H-furan-2-ones in the presence of trifluoroacetic acid afforded a series of substituted 4-oxo-2-thienylaminobut-2-enoic acids. Anti-inflammatory activity and acute toxicity of the obtained substituted 4-oxo-2-thienylaminobut-2-enoic acids were studied. It was found that the obtained compounds have a pronounced anti-inflammatory activity and low toxicity.

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Funding

The research was supported by the Perm Research and Education Centre for Rational Use of Subsoil, 2021.

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Authors and Affiliations

  1. Perm State University, 614990, Perm, Russia

    D. A. Shipilovskikh, R. R. Makhmudov, A. E. Rubtsov & S. A. Shipilovskikh

  2. Perm National Research Polytechnic University, 614990, Perm, Russia

    D. A. Shipilovskikh

  3. ITMO University, School of Physics and Engineering, 197101, St. Petersburg, Russia

    S. A. Shipilovskikh

Authors
  1. D. A. Shipilovskikh
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  2. R. R. Makhmudov
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  3. A. E. Rubtsov
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  4. S. A. Shipilovskikh
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Correspondence to S. A. Shipilovskikh.

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The studies were performed in accordance with all applicable international, national and institutional guidelines for the care and use of animals. The authors declare no conflicts of interest.

Additional information

Translated from Zhurnal Obshchei Khimii, 2021, Vol. 91, No. 10, pp. 1587–1593 https://doi.org/10.31857/S0044460X21100152.

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Shipilovskikh, D.A., Makhmudov, R.R., Rubtsov, A.E. et al. Hydrolysis of Substituted 3-(Thien-2-yl)imino-3H-furan-2-ones and Anti-Inflammatory Activity of the Reaction Products. Russ J Gen Chem 91, 2025–2030 (2021). https://doi.org/10.1134/S1070363221100157

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