Abstract
Synthesis of twelve novel regioselective 1,4-benzoxazine-isoxazole hybrids as in vitro anticancer agents via Cu(I) catalyzed one-pot reaction of various terminal alkynes with 3-(3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl)propanal in benign aqueous t-butanol at room temperature is presented herein. Five products have demonstrated promising activity, among those the compound 6f demonstrates outstanding activity towards PC3, A549, MCF-7, and HeLa with IC50 values of 2.61, 3.34, 2.74, and 7.04 μM respectively.
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Benarjee, V., Saritha, B. & Sailaja, B.B.V. Design and Synthesis of Some New 1,4-Benzoxazine-Isoxazole Hybrids as In Vitro Anticancer Agents. Russ J Gen Chem 91, 1783–1788 (2021). https://doi.org/10.1134/S1070363221090255
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DOI: https://doi.org/10.1134/S1070363221090255