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A Triphenylamine Derivative-based Fluorescent Probe with Good Water Solubility for Targeting Aβ Plaques in Alzheimer’s Disease

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Abstract

A triamine aryl pyrazole-based NIR fluorescent probe with good water solubility has been developed for detecting and imaging Aβ aggregates in Alzheimer’s disease. In vitro studies have demonstrated that the probe high affinity to Aβ aggregates with an increase of fluorescence intensity have been due to the intramolecular charge transfer effect. The probes can specifically image Aβ plaques in brain sections of triple transgenic AD mice.

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Funding

This research was financially supported by the Natural Science Foundation of Anhui Province (no. 1808085MB47), Department of Education Committee of Anhui Province and the Center for Anhui Province Engineering of Modern Chinese traditional medicine (no. KJ2017A291).

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Authors and Affiliations

  1. Department of Pharmacy, Anhui University of Chinese Medicine, 230012, Hefei, China

    J. F. Wang, K. Li & S. S. Zhou

  2. Qlu School of Medicine Shandong University, 502100, Jinan, China

    Y. Zhou

  3. Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, 230601, Hefei, China

    G. Y. Xu & S. S. Zhou

Authors
  1. J. F. Wang
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  2. Y. Zhou
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  3. G. Y. Xu
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  4. K. Li
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  5. S. S. Zhou
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Correspondence to G. Y. Xu or S. S. Zhou.

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Wang, J.F., Zhou, Y., Xu, G.Y. et al. A Triphenylamine Derivative-based Fluorescent Probe with Good Water Solubility for Targeting Aβ Plaques in Alzheimer’s Disease. Russ J Gen Chem 91, 1748–1756 (2021). https://doi.org/10.1134/S1070363221090218

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