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New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: Synthesis, Structure, and Analgesic Activity

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Abstract

A series of new hybrid molecules containing 2-furyl and partially saturated pyridine fragments was obtained based on the reaction of cyanothioacetamide with furfural and 1,3-dicarbonyl compounds. The resulting compounds were tested in vivo for analgesic activity (rats) in the orofacial trigeminal pain test. Some the tested compounds showed an antinociceptive effect, superior to that of the reference drug (metamizole sodium).

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ACKNOWLEDGMENTS

The studies were carried out using the equipment of the research and educational center “Diagnostics of the structure and properties of nanomaterials” of the Kuban State University.

Funding

This study was supported by the Kuban Science Foundation within the framework of the scientific project MFI-20.1-26/20 (application no. MFI-20.1/45), as well as the Ministry of Education and Science of the Russian Federation (project 0795-2020-0031).

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Authors and Affiliations

  1. St. Luke Lugansk State Medical University, 91045, Lugansk, Ukraine

    D. S. Krivokolysko, E. Yu. Bibik, A. A. Samokish & Yu. S. Venidiktova

  2. Kuban State University, 350040, Krasnodar, Russia

    V. V. Dotsenko

  3. North Caucasus Federal University, 355009, Stavropol, Russia

    V. V. Dotsenko, N. A. Aksenov & I. V. Aksenova

  4. V. Dahl Lugansk State University, 91034, Lugansk, Ukraine

    K. A. Frolov, S. G. Krivokolysko & A. A. Pankov

  5. Kuban State Technological University, 350072, Krasnodar, Russia

    V. K. Vasilin

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  1. D. S. Krivokolysko
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  2. V. V. Dotsenko
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Corresponding author

Correspondence to V. V. Dotsenko.

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All procedures performed in studies with animals were in accordance with the ethical standards of the institution in which the studies were carried out, and the approved legal acts of the Russian Federation and international organizations.

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Translated from Zhurnal Obshchei Khimii, 2021, Vol. 91, No. 9, pp. 1359–1374 https://doi.org/10.31857/S0044460X21090079.

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Krivokolysko, D.S., Dotsenko, V.V., Bibik, E.Y. et al. New 4-(2-Furyl)-1,4-dihydronicotinonitriles and 1,4,5,6-Tetrahydronicotinonitriles: Synthesis, Structure, and Analgesic Activity. Russ J Gen Chem 91, 1646–1660 (2021). https://doi.org/10.1134/S1070363221090073

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